By Chauncey Devega  Donald Trump's presidency and the destructive forces it unleashed are a mental health emergency — as well as a public health emergency in general. Trump may no longer be president, but his fascist political movement and the political party he controls continues to cause harm. Trumpism is both a political cult and a manifestation of collective narcissism. Tens of millions of his followers now live in an alternate reality sustained by the Big Lie, an upside-down world in which Donald Trump is still the "real" president of the United States. Many of Trump's followers believe that he should be returned to power by any means available, including terrorism and other political violence. The Trump regime and Republican policies more generally have literally caused trauma — physical, emotional, psychological and spiritual — for millions of Americans, including of course the deaths of at least 700,000 people from the coronavirus pandemic. Dr. Seth D. Norrholm is a translational neuroscientist and one of the world's leading experts on PTSD and fear. He is currently scientific director at the Neuroscience Center for Anxiety, Stress, and Trauma (NeuroCAST) in the Department of Psychiatry and Behavioral Neurosciences at Wayne State University School of Medicine. The revelations that are merging from various sources who had access to the Trump White House are not at all surprising. As I and others have commented on for years now, no matter how you label or classify the former president's behavior (malignantly narcissistic, sociopathic, psychopathic, abusive), there is an underlying thread of immaturity. This immaturity plays itself out as an inability to regulate emotion, a behavioral profile typically seen in children and adolescents. It is therefore not surprising to hear about the former president's uncontrollable rage and the allegation that he had a handler specifically tasked with soothing him like a toddler. I expect similar stories to continue to come out. 

A newly published study found that women who contract COVID-19 during pregnancy are at significantly higher risk of developing preeclampsia, the leading cause of maternal and infant death worldwide. The research, published in the American Journal of Obstetrics and Gynecology, shows that women with SARS-CoV-2 infection during pregnancy had 62% higher odds of developing preeclampsia than those without the infection during pregnancy. The research was led by Roberto Romero, M.D., DMedSci, chief of the Perinatology Research Branch and professor of molecular obstetrics and genetics at the Wayne State University School of Medicine, and Agustin Conde-Agudelo, M.D., M.P.H., Ph.D., adjunct professor of obstetrics and gynecology. “This association was remarkably consistent across all predefined subgroups. Moreover, SARS-CoV-2 infection during pregnancy was associated with a significant increase in the odds of preeclampsia with severe features, eclampsia and HELLP syndrome,” said Dr. Romero.

The Biopsychosocial Health lab from Wayne State University has been awarded $3,590,488 from the National Heart, Lung and Blood Institute of the National Institutes of Health to conduct a project titled “Stress and Cardiovascular Risk Among Urban African American adults: A Multilevel, Mixed Methods Approach.”  The project, led by Samuele Zilioli, Ph.D., assistant professor in the Department of Psychology and the Department of Family Medicine and Public Health Sciences at Wayne State University, aims to provide a fine-grained characterization of the psychosocial factors associated with cardiovascular disease (CVD) risk and inflammation among urban middle-aged and older African American adults.  According to Zilioli, despite the steady decline in CVD morbidity and mortality in the U.S. over the last few decades, African American adults bear a disproportionate share of CVD burden.” Most of the research in this area has focused on proximate medical risk factors — such as diabetes and dyslipidemia — for CVD risk,” said Zilioli. “Only recently, however, have researchers started to consider the role of more distal risk factors, such as psychosocial stressors.” 

By Danielle Salisbury  Farm stores are hanging safety alerts and health authorities are warning ivermectin, approved for use in humans with parasitic worms and also given to large animals, is not proven to treat or prevent COVID-19, despite some seemingly continually circulating information to the contrary. “It hasn’t been shown to be safe or effective for that specific indication,” said Dr. Varun Vohra, director of the Michigan Poison & Drug Information Center at the Wayne State University School of Medicine, which has been fielding some calls on the drug and issued a warning statement on Tuesday. Taking formulations intended for livestock, to prevent heartworm disease and certain internal and external parasites, is especially concerning. Horses and cows are much larger than average humans, he said. “So the dose is going to be consistent with that. They’re going to be a lot more concentrated. So, the threshold for toxicity can be a lot lower.” 

We’ve all been there: whether it's pulling a late-night study session, nursing a newborn baby at 4 a.m., or working long hours to meet a deadline, a lot can come between you and your pillow. You may chalk up sleep debt as an inescapable part of life. But a growing body of sleep-medicine research is shedding light on just how much damage too little sleep can cause. New research suggests that recovery from sleep deprivation (many days of it, in particular) may not be so easy. The effects of sleep deprivation on the brain’s attention and cognitive processing abilities may linger as long as a week after we’ve returned to a regular sleep routine, warns a new study, published September 1 in the journal PLoS One. Ultimately, you should think twice before you pull another all-nighter. While you may feel refreshed after a subsequent good night’s rest, your body may still feel the effects of your late nights, says James Rowley, MD, a professor of critical care and sleep medicine at Wayne State University in Detroit. This research is more evidence that you can’t quickly make up for lost sleep if you’re chronically sleep deprived, he says. “In the long run, it’s better to avoid the sleep debt in the first place and try to get seven hours of sleep consistently seven nights per week.” 

Overdosing on the drug ivermectin can be scary, with symptoms that can include everything from nausea and vomiting to hallucinations and even death. While ivermectin has been used to treat people with certain conditions, like head lice and rosacea, the FDA and the CDC have seen an uptick of reports of misuse and overdose. “If they’re using the veterinary formulations, you have to realize that these medications, or these formulations, specifically, are designed for animal use. And these are animals that are significantly larger than the average human if we’re talking about horses and cows,” said Dr. Varun Vohra with the Michigan Poison & Drug Information Center at Wayne State University.  

By Jake Bekemeyer  The State of Michigan has awarded Wayne State University in Detroit a $7 million grant to investigate the potential therapeutic effects of cannabis to improve military veteran patients’ quality of life and reduce post-traumatic stress disorder and depressive symptoms that can precede suicide. The grant was awarded as part of the Department of Licensing and Regulatory Affairs’ Marijuana Regulatory Agency’s 2021 Veteran Marijuana Research Grant Program. Leslie Lundahl, associate professor of psychiatry and behavioral neurosciences at the WSU School of Medicine, is the lead principal investigator on the five-year project — Wayne State Warriors Marijuana Clinical Research Program: Investigating the Impact of Cannabinoids on Veteran’s Behavioral Health. 

Arash Javanbakht, associate professor of psychiatry, wrote a piece for The Conversation. “Images of tragedy, loss of entire communities and the terrible destruction wrought by deadly wildfires in the West have sadly become all too common. But the public hears relatively little about the suffering of the firefighters who risk their lives and are away from their families for days and weeks at a time…While the choice to become a firefighter often stems from a passion for, and a mindset of, helping others and saving lives, being constantly exposed to death, injury and suffering comes with a cost. Cumulative stressors include the physical toll on the body, long working hours, work-related sleep disturbance and an inability to attend to daily family life. I am a psychiatrist and trauma expert who often works with first responders as well as refugees and victims of war crimes. While many people think of firefighters as the happy heroes, the real-life, day-to-day experiences of these heroes can have real consequences for their mental health that remain largely invisible to the public eye.”

A Wayne State University School of Medicine researcher has been awarded a $1.93 million, five-year grant by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health to study the impact of maternal immunoglobulin D (IgD) transferred to the fetus during pregnancy and its impact on protecting against food allergies. Kang Chen, Ph.D., associate professor of obstetrics and gynecology will use the grant, “Mechanism and function of transplacental IgD,” to tackle early infant morbidity due to increasing incidences of food allergies. “This project, funded by the National Institutes of Health, will allow our research team to elucidate the mechanisms of the placental transfer of IgD and determine if maternal IgD promotes neonatal immune protection against food allergy,” said Chen. “Our studies have shown that maternal IgD specific to vaccines or food acts as a specific and prophylactic fetal immune education cue to protect neonates against food allergy. Our research will have a major impact on our understanding of the origin of allergies in newborns and children.” Chen’s  study is expected to reveal the unique functions of maternal IgD — an ancient yet still mysterious antibody — in neonatal immune function that maternal Immunoglobulin G (IgG) does not have, and aims to have a profound impact on improving neonatal health by directing the design of IgD-targeting maternal vaccines or adoptive immunotherapies.

Detroit Public Schools Community District will require masks be worn by all students and staff inside its buildings for the school year beginning Sept. 7. DPSCD had previously adopted a mask policy that would allow those fully vaccinated to not wear masks in classrooms but pushed for a change after the U.S. Centers for Disease Control and Prevention updated its recommendations that all people, including those vaccinated against COVID-19, should return to wearing masks at crowded indoor locations including schools. Teena Chopra, chief of infectious diseases at Wayne State School of Medicine and a Detroit Medical Center physician, said schools, particularly those in areas with elevated community spread of the coronavirus, should be mandating mask wearing given the rising delta variant. "I think it is deadly and dangerous behavior to not require masks," Chopra said. "This virus is extremely unforgiving and elementary age children, they are completely unprotected. Mask mandates have to be there until community transmission goes down. That can happen as soon as people get vaccinated. This is not the time to dwell on breakthrough infections, but to increase vaccinations across the nation," Chopra said. "Our children are going to suffer the most. We are seeing severe infections in children. There are children that are in ICUs (intensive care units) and (on ventilators). The breakthrough infections are there. Vaccines are not there to prevent breakthrough infections. They are there to prevent severe illness and hospitalization and death."

Wayne State University announced Monday the opening of a new center focused on the study of infectious diseases and strategies to combat future pandemics. The Center for Emerging and Infectious Diseases will enhance training and research in the field of public health. The center is not a physical building but a collection of doctors, researchers and professors at the Detroit-based university. "The COVID-19 pandemic has dramatically altered local, state and national mindsets toward infectious disease threats, including pandemic diseases," Dr. Mark Schweitzer, dean of Wayne State's School of Medicine and vice president of health affairs for the university, said in a news release. "The pandemic revealed deep and broad gaps in our clinical and public health infrastructure that responds to pandemics. "In line with the mission of WSU to support urban communities at risk for health disparities, the center will have the expertise and capacity to support and collaborate with neighborhoods, hospitals and public health agencies to deliver state-of-the-art diagnostics, treatments and preventive strategies for the benefit of all residents in Detroit and other communities." Work done at the center will focus on vaccine development, clinical vaccine evaluational, deployment strategies for the vaccine in underserved populations and research on pandemic mitigation efforts. Directors of the new center include: Dr. Teena Chopra, professor of medicine in the division of infectious diseases; Dr. Paul Kilgore, associate professor of pharmacy practice; Dr. Marcus Zervos, head of infectious diseases division for Henry Ford Health System, professor of medicine and assistant dean of WSU Global Affairs. Key faculty include Dr. Phillip Levy, professor of emergency medicine and assistant vice president of translational science and clinical research at WSU, and Matthew Seeger, professor of communication.

The United States has finally reached a goal set by President Joe Biden to get 70% of adults with at least one dose of a COVID-19 vaccine. However, it's coming in the midst of a surge of cases nationwide. Right now, 47 states, including Michigan, are categorized as "high or substantial" community transmission. Five states are in such bad shape, they accounted for nearly half the new cases across the country last week. Dr. Teena Chopra, a professor of infectious diseases at Wayne State University, said the delta variant of COVID-19 is spreading fast, and the viral load is 1,000 times than that of the original virus. "We need to keep moving forward and we need to move forward with our vaccinations rates faster than before because we don't want to give this virus a chance to win," Chopra said. As of Monday, 33 of Michigan's 83 counties – including Oakland, Macomb and Livingston – are considered to have substantial or high transmission rates. In these areas, the CDC advises both the vaccination and unvaccinated wear masks. Late last week, just 10 rural counties fit the CDC's criteria. Michigan health officials are worried that if the virus keeps replicating, the next variant might escape vaccination. Beaumont Health System currently has 64 COVID-19 patients admitted – 3 of whom are vaccinated. That's .06% of patients having breakthrough cases. "It's a known fact that vaccinations are the only way out of his pandemic and when we have that tool in our tool box the community has to get vaccinated and help each other through those tough times," Chopra said.

Wayne State University has been awarded millions of dollars to study high blood pressure in Detroit residents. The new project will deploy mobile health clinics to Detroit neighborhoods over the next four years to better understand the factors that contribute to hypertension in residents. It's part of a $20 million initiative to better understand the health disparities between Black and White Americans. The plan is to identify health plans for residents with high blood pressure and help cultivate a personal regiment that will coach them toward a healthier lifestyle. Data collected from these plans will better help researchers understand what role environmental factors contribute in the overall health outcome of Detroiters. Wayne State will be using $2.6 million for the program. A professor of emergency medicine at Wayne State that is leading the program says access to health care, food insecurity, availability of healthy food, shelter, and exercise are all major factors in high blood pressure. "To achieve health equity, effective strategies must address negative (social determinants of health) that are root causes of racial disparities in health," said Dr. Phillip Levy. Levy said that while lifestyle changes could better improve the health outcomes for people with high blood pressure, implementing these changes has not been easy.

COVID-19 overshadowed the opioid crisis in Michigan last year, but newly released data suggests the pandemic may have helped fuel an increase in drug deaths. Drug overdose deaths in 2020 climbed 16 percent in Michigan over the previous year — reaching an all-time high of 2,743 deaths, according to preliminary data released this week by the U.S. Centers for Disease Control and Prevention. Nationally, there were more than 93,000 drug deaths last year, a 30-percent jump. Experts attribute the spike to the isolation and strangeness of a pandemic that ground down the mental health of so many, but especially those who fought addiction. “Isolation, loss of job insecurity — all of those things are big-time stressors for anybody,” said Dr. Andrew King, an addiction specialist with the Wayne State University’s physicians group and an emergency room doctor at Detroit Medical Center’s Receiving Hospital. “People with substance use disorder in particular, might be at a higher risk of returning to use, potentially overdosing,” he said. The synthetic opioid (fentanyl), which is 50 times or more powerful than morphine, was found in 72 percent of the drug-overdose cases, or 208 cases. In the previous two years, it was present in about half of the overdose cases. “Any hit of heroin is like playing Russian roulette. It's potentially deadly,” said King, the Detroit emergency room doctor. “It's very rare now for me to see any patient who has not been exposed to fentanyl. Fentanyl is almost ubiquitous.” And because people were less likely to be with loved ones or friends during the pandemic, they were less likely to have someone close when they overdosed to administer naloxone, an emergency medication that’s used to reverse opioid overdoses. King tells patients that, if they’re going to use, be with someone with naloxone. “But in the case of the pandemic, if people are more isolated and not socializing, then sometimes it can be too late,” he said.

As COVID cases drop in the U.S. and vaccinations increase, many companies are bringing their employees back to office buildings. And lots of those workers are worried: Will shared spaces remain safe as restrictions are lifted and viral variants spread? Can businesses require all employees to be vaccinated? What office and building features best minimize risk? If you’re vaccinated, you can return to work as normal (mostly). The most effective way to reduce the spread of the coronavirus at work is to make sure that everyone in the shared space is vaccinated. Current guidelines from the Centers for Disease Control and Prevention specify that fully vaccinated people (those who are two weeks past their final vaccine dose) no longer need to wear a mask or practice physical distancing in most situations, including most office workplaces. COVID vaccines are highly effective at preventing infection and illness, so once you are fully vaccinated, “it doesn’t really matter what the vaccine status is of those around you,” says Gretchen Snoeyenbos Newman, an infectious disease physician at Wayne State University. If you’re returning to a workplace where some of your co-workers are unwilling or unable to get vaccinated or to wear a mask, the best protection you have is getting immunized yourself, she says.

A Wayne State University School of Medicine faculty member is editor of a newly published book, Brain Network Dysfunction in Neuropsychiatric Illness: Methods, Applications & Implications. Vaibhav A. Diwadkar, Ph.D., professor of psychiatry and behavioral neurosciences at Wayne State, and his colleague, Simon Eickhoff, Ph.D., from Heinrich-Heine University in Dűsseldorf and Institute of Neuroscience and Medicine in Forschungszentrum Jülich, Germany, were invited co-editors of the volume, which is published by Springer Nature Publishing, a subsidiary of the Nature Publishing Group, one of the largest scientific publishing houses in the world. The volume is a unique compendium of diverse chapters from more than 40 of the world's leading experts in the fields of brain imaging, computational and analytic methods, and neuropsychiatry. It is the first collection of its kind to focus attention specifically on the challenging problem of understanding how abnormal brain network function might give rise to debilitating conditions such as schizophrenia, depression, mood disorders, borderline personality disorder, attention deficit hyperactivity disorder and autism.

The Office of Women’s Health at Wayne State University, in partnership with the Wayne Health Mobile Unit program, will introduce Well-Woman Wednesdays, bringing free mobile health screenings and health education to the community at a variety of locations beginning July 14. The first Well-Woman Wednesday will take place from 2 to 6 p.m. at the headquarters of Alternatives for Girls. The project seeks to educate and empower women to achieve better health by providing them with screening, resources and connections to health care providers on their journey to improved wellness. “With Well-Woman Wednesdays, the Wayne State University Office of Women’s Health aims to expand health care to vulnerable communities impacted most by health disparities and lack of access to health care, thus improving the health of women overall,” said Sonia Hassan, M.D., associate vice president and founder of the Office of Women’s Health and a professor of Obstetrics and Gynecology at Wayne State University. “The development of a women-focused mobile health unit aiming to improve health literacy and provide reliable methods and resources for the establishment and pursuit of care will improve accessibility of health care to women and eventually narrow the gap in health disparities.” The Wayne Health Mobile Unit program began in April 2020, bringing COVID-19 testing, and later vaccinations, to tens of thousands of people across Michigan. “This latest project is an extension of our initial testing and vaccination efforts,” said Phillip Levy, M.D., M.P.H., a WSU professor of Emergency Medicine and chief innovation officer for Wayne Health. “It makes perfect sense to expand the array of health care and health care education services that our mobile units can provide for communities, assisting people in the comfort of their own surroundings.”

Cases of influenza plummeted during the COVID-19 pandemic, with one Detroit health system having a zero percent positivity rate for the virus, a new study finds. Researchers from Wayne State University looked at data from the Detroit Medical Center for the 2019-20 and the 2020-21 flu seasons. They found that every single one of the 6,830 tests administered for adults, and the 1,441 for children came back negative for Influenza A and Influenza B during the 2020-21 (September 2021 to February 2021) flu season. There were also zero positive tests for respiratory syncytial virus (RSV) in adults - out of 6,822 - and one for children among 1,404 tests. The findings add to the wealth of existing information that shows social distancing and mask mandates put in place to protect from COVID-19 were effective in combatting the flu. Researchers expect cases of the flu to return to normal levels now, though, as many COVID precautions are dropped around the country. 'It is likely that the number of cases of flu and other respiratory infections will rise back to normal in the coming years as SARS-CoV-2 becomes a seasonal virus,' said Siri Sarvepalli, a member of the research team at Wayne State. 'However, if handwashing and other mitigating measures are followed to the same extent as last winter, numbers could instead remain lower than usual.'  The team will present its findings at the European Congress of Clinical Microbiology & Infectious Diseases this week. 

Wayne State University and Henry Ford Health System announced today the launch of a basic and translational research initiative in Cardiometabolic Health and Disease as a thematic focus for program growth. The Integrated Research and Development Initiative in Cardiometabolic Health and Disease will focus on program strengths at both institutions that directly addresses health issues of cardiac disease, hypertension, diabetes, obesity metabolism and kidney disease that are of particular relevance for the broad communities that the two institutions serve. “We are excited and pleased to be bringing our two institutions together to better serve our community’s cardiovascular needs,” said Mark E. Schweitzer, M.D., dean of the Wayne State University School of Medicine. “Heart disease is the leading cause of death in Michigan, and by joining forces with the excellent team at Henry Ford Health System, we aim to reverse this trend.”

A two-day virtual 2021 Child & Adolescent Behavioral Health Summit, held April 13-14, invited professionals and insiders to address critical topics related to mental health, wellness, substance use disorder and suicide prevention. The event was designed for clinicians, social service providers, educators, parents, and anyone who works with youth. “What is the worst stress you’ve experienced in your life?” This question can help mental health professionals get to the core of a patient’s distress. But, according to Dr. Arash Javanbakht, director of the Stress, Trauma and Anxiety Research Clinic (STARC) at Wayne State University, it often goes unasked. Javanbakht led a session on the role of trauma and Post-Traumatic Stress Disorder (PTSD) during the summit. He explained that about 8 percent of Americans suffer from PTSD, described as an overgeneralization of fear, when memories are not where they belong in a person’s timeline. With PTSD, the brain reacts as if things are happening now, not as a memory. The brain is trained to be in a constant survival mode, making normal life nearly impossible to enjoy. Javanbakht said that diagnosing PTSD is not always a part of a children’s mental health professional’s training. “The two things you have to ask about are usually not volunteered: sex life and trauma,” he advises mental health professionals. “Trust is hard, especially when it comes to painful memories.” Javanbakht discussed different treatments for PTSD, including a variety of therapy options as well as medications. He said it’s important to see PTSD as a disease that can be treated.