As omicron COVID-19 cases skyrocket in Michigan, hospitalizations are increasing as well – although at a far slower rate – and prompting concerns about capacity. Even though the variant is mild for most, the wave has increased hospital admissions statewide by 400 in one week, a 10% rise, while forcing hundreds of critical health care workers to quarantine. Just a few weeks after hospitalizations dropped from a peak of nearly 4,800 patients, the health care system is girding again for another COVID-19 crunch, which may be less lethal but could tax its ability to provide care. On Monday the state reported 61,235 new infections for the past five days, an average of 12,247. For the past week, the daily average of 12,442 is up 65% from the previous week’s average of 7,533 daily cases. Dr. Teena Chopra, director of the Center for Emerging and Infectious Diseases and a professor at Wayne State University School of Medicine works with local hospitals and said that although a smaller fraction of those who get infected are requiring hospital care, the previously unseen scale of infections is still leading to hundreds of people sick enough to require a hospital visit, especially in Detroit which has one of the lowest vaccination rates in the state. “The sheer numbers are so huge, the hospitals are getting overwhelmed,” Dr. Chopra said.

By Darren Cunningham  The interest in keeping up with COVID and its variants varies from person to person. Some opt to just follow the protocols; others want to know the science behind the severity and transmissibility. Scientists say the newest strain, omicron, spreads quicker than delta but is less severe. Doctors, including Dr. Phillip Levy, a professor of emergency medicine and researcher at Wayne State University, said it's important to keep in mind most of the studies on omicron so far have been conducted in South Africa, a different population with younger people being infected. “So, when you say, ‘could it be more severe?’ It wouldn’t be more severe because omicron itself becomes something different. I mean that could happen, and it may create a new severe variant which would have a new Greek alphabet naming structure. But omicron itself, we still just don’t know what it’s going to do when it hits our population,” said Dr. Levy.

Wayne Health has been hosting drive-through clinics on Mack Avenue to provide monoclonal antibody treatments, which can be the difference between life and death for those most vulnerable to severe illness from COVID-19. But amid Michigan’s worst-yet coronavirus surge, there’s not enough supply of monoclonal antibodies nor are there enough health care workers to administer them. “COVID testing and vaccinations remain our pillar, but we’re also very heavily engaged in monoclonal antibody infusions, which are a great way to prevent people who do contract COVID – particularly high-risk individuals – from getting sick to the point where they require hospitalization or at risk for dying,” said Dr. Phillip Levy, professor of emergency at Wayne State University, chief innovation officer for Wayne Health, and assistant vice president for research. Levy said when the virus attacks the body, it’s like an internal war in which coronavirus particles are the invaders pitted against the antibody soldiers a person’s immune system has called to defend it. “The monoclonal antibodies basically are a pharmaceutical version of the antibodies your body would produce anyway to fight off the virus. And by taking these antibodies and sort of bolstering your natural immune system, you get more soldiers, more fighters against the virus,” said Dr. Levy.  

Hilary Marusak, assistant professor of psychiatry and behavioral neurosciences at Wayne State University, wrote an article sharing an explanation of the impact exercise has on the body’s natural cannabinoids and the associated benefits for mental health and stress relief. The “runner’s high” has long been attributed to endorphins, but research from Marusak’s lab found that exercise reliably increases levels of the body’s endocannabinoids – which are molecules that work to maintain balance in the brain and body – in a process called “homeostasis.” This natural chemical boost may better explain some of the beneficial effects of exercise on brain and body.  

Santa made a recent visit to Detroit to spread holiday cheer and help encourage community members to get vaccinated. A Wayne Health Mobile Unit provided COVID-19 vaccines, as well as flu shots and other screenings, at the pop-up clinic at Saunders Memorial A.M.E. Church. The event also featured ice sculptures and food.  

Scientists at the John A. Moran Eye Center at the University of Utah have discovered a new type of nerve cell, or neuron, in the retina. The discovery marks a notable development for the field as scientists work toward a better understanding of the central nervous system by identifying all classes of neurons and their connections. The research team named their discovery the Campana cell after its shape, which resembles a hand bell. The published research study, “An uncommon neuronal class conveys visual signals from rods and cones to retinal ganglion cells,” was authored by Tushar Ganjawala, a Ph.D. student in the Wayne State University School of Medicine, and co-authors Brent K Young, Charu Ramakrishnan, Ping Wang, Karl Deisseroth, and Ning Tian. The work was supported by an NIH Core Grant, and an Unrestricted Grant from Research to Prevent Blindness, New York, NY, to the Department of Ophthalmology & Visual Sciences, University of Utah, and the Department of Ophthalmology of Wayne State University School of Medicine; additional support was provided by the Ligon Research Center of Vision, Kresge Eye Institute, and the Dryer Foundation. 

Chest pain is about more than pain in the chest. But when it comes on suddenly, experts behind new guidelines on evaluating and diagnosing it don’t want you pondering nuances. They want you to act – now. “The most important thing people need to know about chest pain is that if experience it, they should call 911,” said Dr. Phillip Levy, a professor of emergency medicine and assistant vice president for research at Wayne State University. “People shouldn’t waste time trying to self-diagnose. They should immediately go to the nearest hospital. And if they’re going to go to the nearest hospital to get evaluated for chest pain, ideally it should be by ambulance.” Levy helped lead the committee that wrote the new guidelines from the American Heart Association and American College of Cardiology.  

By Megan Edwards  Wayne State University School of Medicine in Detroit is the first college in the United States to introduce a mandatory plant-based nutrition unit into their curriculum for first-year medical students. The four-week “Rooting for Wellness” learning module, launched in 2019, utilizes recorded lectures, online quizzes, cooking demonstrations, guest lecture panels, and a vegan community fair to teach students about the critical connection between nutrition and disease prevention. The curriculum’s creators recently published a report in the International Journal of Disease Reversal and Prevention about the success of the program and how other universities can follow their lead.  “I’ve always been passionate about community advocacy, nutrition, and the promotion of preventive medicine, but was disappointed by how sparingly these topics were covered in med school,” said Lakshman Mulpuri, a co-founder of Rooting for Wellness and student at the university. “I was in awe of the incredible stories of patients who had empowered themselves with a whole-food, plant-based diet. I knew that these stories and the science behind them needed to be shared with my fellow fledgling physicians.” 

By Alex Bozarjian  Researchers are learning more about how severe cases of COVID-19 can impact a person's mental health in the long term. A study conducted in Italy found that 30% of patients who recovered from COVID-19 developed post-traumatic stress disorder (PTSD). "This brain goes to fight or flight mode, and people have nightmares, people have flashbacks, and these flashbacks are as if I am there, I see things, I hear things--I feel the touches," Dr. Arash Javanbakht said. He researches stress, trauma and anxiety at Wayne State University. He said there are a lot of layers to recovery after COVID-19. It can either be mental or physical. 

Exposure to air pollution and road traffic noise over several years may increase the risk of heart failure, according to new research from a large observational study. The study examined more than 22,000 female nurses based in Denmark, aged 44 and older, over a period of 15 to 20 years to evaluate the impact of exposure to small particulate matter and nitrogen dioxide, as well as road traffic noise. The results showed that increased exposure to these pollutants after just 3 years was tied to a substantially increased risk of new heart failure. With emissions standards now in place to combat pollution, it is interesting that the researchers thought to explore air pollution as a heart failure risk, says Ileana L. Piña, MD, a heart failure transplant cardiologist and professor of medicine at Wayne State University. "You think of respiratory illness in cities where there is a high level of pollution, but you don't think of heart failure," says Piña, who was not a part of this study. "Next I think we need to link up what it was in that polluted air that actually caused the trauma." 

Health care disparities in Black, Brown and impoverished populations are well documented, but the outcomes have never been as obvious as during the pandemic. For instance, in 2020, Black people were 2.1 times more likely than white people to die from COVID-19 in the U.S. In Michigan last year, roughly 30 out of every 1,000 Black people living in Michigan could expect to die from COVID-19, according to data published by Brookings Institution last March. To improve access to health care, the system must go mobile, said Dr. Philip Levy, professor of emergency medicine at Wayne State University and chief innovation officer for Wayne Health. Levy's practice is attempting to reinvent the model by putting primary preventive care on wheels and meeting patients where they live in an attempt to overcome systemic problems by treating chronic conditions like high blood pressure. The pandemic has also led to the most critical staffing crisis the industry has ever faced. Nationally, roughly 30 percent of nurses have either quit or been terminated during the pandemic. 

Avoiding fast foods, soda pop and processed foods can help prevent a condition called metabolic syndrome, or MetS for short. Diet changes often are far more powerful for preventing disease than the treatments we get when problems such as obesity, diabetes mellitus, high blood pressure, heart attacks and strokes are fully developed. The old saying is true: An ounce of prevention is worth a pound of cure. A syndrome means we diagnose a condition by a constellation of findings without a single definitive test. These are factors for MetS: Abdominal obesity Low HDL cholesterol High triglycerides Elevated fasting blood levels of glucose Elevated blood pressures This syndrome is present in an estimated 30 percent of the U.S. population. and probably more than that among Detroiters. Those with MetS have a fivefold increase in the risk of developing type 2 diabetes mellitus (DM2) and twice the risk for heart disease over five to ten years. While there are obese individuals who don't show MetS, the diagnosis has become more common with a rise in the percentage of people worldwide who are overweight or obese.

BY Jen Christensen  Pregnant women who develop Covid-19 symptoms risk emergency complications and other problems with their pregnancies, according to two new studies. The disease also puts their children at risk. Dr. Gil Mor, a reproductive immunologist who did not work on the study but reviewed the work, said it's also possible that the problems could be related to chronic inflammation caused by Covid-19. "Inflammation is extremely dangerous for both the mother and the development of the fetus. A chronic inflammation is now a fight for the survival of the mother and the fetus, and in every fight, they pay they pay a price," said Mor, who leads a research lab at Wayne State University that studies the immune system during pregnancy and the impact of pathogens. "We need to do everything in our hands in order to prevent the chronic inflammation." 

By Chauncey Devega  Donald Trump's presidency and the destructive forces it unleashed are a mental health emergency — as well as a public health emergency in general. Trump may no longer be president, but his fascist political movement and the political party he controls continues to cause harm. Trumpism is both a political cult and a manifestation of collective narcissism. Tens of millions of his followers now live in an alternate reality sustained by the Big Lie, an upside-down world in which Donald Trump is still the "real" president of the United States. Many of Trump's followers believe that he should be returned to power by any means available, including terrorism and other political violence. The Trump regime and Republican policies more generally have literally caused trauma — physical, emotional, psychological and spiritual — for millions of Americans, including of course the deaths of at least 700,000 people from the coronavirus pandemic. Dr. Seth D. Norrholm is a translational neuroscientist and one of the world's leading experts on PTSD and fear. He is currently scientific director at the Neuroscience Center for Anxiety, Stress, and Trauma (NeuroCAST) in the Department of Psychiatry and Behavioral Neurosciences at Wayne State University School of Medicine. The revelations that are merging from various sources who had access to the Trump White House are not at all surprising. As I and others have commented on for years now, no matter how you label or classify the former president's behavior (malignantly narcissistic, sociopathic, psychopathic, abusive), there is an underlying thread of immaturity. This immaturity plays itself out as an inability to regulate emotion, a behavioral profile typically seen in children and adolescents. It is therefore not surprising to hear about the former president's uncontrollable rage and the allegation that he had a handler specifically tasked with soothing him like a toddler. I expect similar stories to continue to come out. 

A newly published study found that women who contract COVID-19 during pregnancy are at significantly higher risk of developing preeclampsia, the leading cause of maternal and infant death worldwide. The research, published in the American Journal of Obstetrics and Gynecology, shows that women with SARS-CoV-2 infection during pregnancy had 62% higher odds of developing preeclampsia than those without the infection during pregnancy. The research was led by Roberto Romero, M.D., DMedSci, chief of the Perinatology Research Branch and professor of molecular obstetrics and genetics at the Wayne State University School of Medicine, and Agustin Conde-Agudelo, M.D., M.P.H., Ph.D., adjunct professor of obstetrics and gynecology. “This association was remarkably consistent across all predefined subgroups. Moreover, SARS-CoV-2 infection during pregnancy was associated with a significant increase in the odds of preeclampsia with severe features, eclampsia and HELLP syndrome,” said Dr. Romero.

The Biopsychosocial Health lab from Wayne State University has been awarded $3,590,488 from the National Heart, Lung and Blood Institute of the National Institutes of Health to conduct a project titled “Stress and Cardiovascular Risk Among Urban African American adults: A Multilevel, Mixed Methods Approach.”  The project, led by Samuele Zilioli, Ph.D., assistant professor in the Department of Psychology and the Department of Family Medicine and Public Health Sciences at Wayne State University, aims to provide a fine-grained characterization of the psychosocial factors associated with cardiovascular disease (CVD) risk and inflammation among urban middle-aged and older African American adults.  According to Zilioli, despite the steady decline in CVD morbidity and mortality in the U.S. over the last few decades, African American adults bear a disproportionate share of CVD burden.” Most of the research in this area has focused on proximate medical risk factors — such as diabetes and dyslipidemia — for CVD risk,” said Zilioli. “Only recently, however, have researchers started to consider the role of more distal risk factors, such as psychosocial stressors.” 

By Danielle Salisbury  Farm stores are hanging safety alerts and health authorities are warning ivermectin, approved for use in humans with parasitic worms and also given to large animals, is not proven to treat or prevent COVID-19, despite some seemingly continually circulating information to the contrary. “It hasn’t been shown to be safe or effective for that specific indication,” said Dr. Varun Vohra, director of the Michigan Poison & Drug Information Center at the Wayne State University School of Medicine, which has been fielding some calls on the drug and issued a warning statement on Tuesday. Taking formulations intended for livestock, to prevent heartworm disease and certain internal and external parasites, is especially concerning. Horses and cows are much larger than average humans, he said. “So the dose is going to be consistent with that. They’re going to be a lot more concentrated. So, the threshold for toxicity can be a lot lower.” 

We’ve all been there: whether it's pulling a late-night study session, nursing a newborn baby at 4 a.m., or working long hours to meet a deadline, a lot can come between you and your pillow. You may chalk up sleep debt as an inescapable part of life. But a growing body of sleep-medicine research is shedding light on just how much damage too little sleep can cause. New research suggests that recovery from sleep deprivation (many days of it, in particular) may not be so easy. The effects of sleep deprivation on the brain’s attention and cognitive processing abilities may linger as long as a week after we’ve returned to a regular sleep routine, warns a new study, published September 1 in the journal PLoS One. Ultimately, you should think twice before you pull another all-nighter. While you may feel refreshed after a subsequent good night’s rest, your body may still feel the effects of your late nights, says James Rowley, MD, a professor of critical care and sleep medicine at Wayne State University in Detroit. This research is more evidence that you can’t quickly make up for lost sleep if you’re chronically sleep deprived, he says. “In the long run, it’s better to avoid the sleep debt in the first place and try to get seven hours of sleep consistently seven nights per week.” 

Overdosing on the drug ivermectin can be scary, with symptoms that can include everything from nausea and vomiting to hallucinations and even death. While ivermectin has been used to treat people with certain conditions, like head lice and rosacea, the FDA and the CDC have seen an uptick of reports of misuse and overdose. “If they’re using the veterinary formulations, you have to realize that these medications, or these formulations, specifically, are designed for animal use. And these are animals that are significantly larger than the average human if we’re talking about horses and cows,” said Dr. Varun Vohra with the Michigan Poison & Drug Information Center at Wayne State University.  

By Jake Bekemeyer  The State of Michigan has awarded Wayne State University in Detroit a $7 million grant to investigate the potential therapeutic effects of cannabis to improve military veteran patients’ quality of life and reduce post-traumatic stress disorder and depressive symptoms that can precede suicide. The grant was awarded as part of the Department of Licensing and Regulatory Affairs’ Marijuana Regulatory Agency’s 2021 Veteran Marijuana Research Grant Program. Leslie Lundahl, associate professor of psychiatry and behavioral neurosciences at the WSU School of Medicine, is the lead principal investigator on the five-year project — Wayne State Warriors Marijuana Clinical Research Program: Investigating the Impact of Cannabinoids on Veteran’s Behavioral Health.