By Herbert Smitherman, Jr. Dr. Herbert Smitherman, Jr., professor at the Wayne State University School of Medicine and president and CEO of Health Centers Detroit Foundation, wrote an opinion piece celebrating the science that allowed us to fight back against a pandemic. “…we are the only generation in human history that has been able to fight back against a pandemic with science through the development of a vaccine, to end that same pandemic in real time. Please do not underestimate what we have accomplished as a human society and the impact of the 2020 COVID vaccine or the science behind it. The literal enormity of isolating the genetic code of COVID-19, developing a vaccine based on historic science, mass producing that vaccine, the logistics of distributing that vaccine across the globe, establishing sites and staff to administer the vaccine, agreeing to public policies and educating the public regarding COVID and the vaccine, getting shots in arms, developing a mechanism to test for the virus and the development of IV and oral treatments for COVID, has been a feat like no other in human history.”

By Danielle Salisbury People who regularly see primary care physicians tend to live long and healthier lives – if they can locate and secure doctors near home, Michigan doctors said. Despite the necessity of such practitioners, who handle patients from birth to death, there are too few of them and trends suggest there will be even fewer as current practitioners age and medical students with six-figure loan debts choose more lucrative specialties. Of Michigan’s 83 counties, 75 are at least partially designated as having shortages in primary care doctors. To address the situation, the state academy is calling on state leaders to invest an additional $31.4 million in existing programs, MIDOCS and the Michigan State Loan Repayment Program. MIDOCS, funded by the state, increases the number of medical residency training slots in primary care and other high-need specialties. Those accepted must commit to two years of practice in a rural or urban underserved area after they complete their residences. In exchange, they may receive up to $75,000 for repayment of eligible educational loans. The program partners with the medical schools at four state universities, including Wayne State.

Around 300 medical students from Wayne State University’s School of Medicine gathered at Motor City Casino on March 18 for Match Day, the nationwide event where medical students find out where they’ll spend their residencies. The event was the first in-person Match Day celebration since 2019. The match rate for School of Medicine students who participated in this year’s match was 97.4%. “I really care about service now that I’ve been in Detroit, so I’m so excited to bring it to the Bronx,” said Emily Nghiem, who matched at her first choice for a general surgery residency at Montefiore New Rochelle Hospital in New York.   

By Kimberly Craig  If you found yourself a tad grumpy Sunday after losing an hour of sleep, you’d be in good company. Studies show that most Americans would like to put an end to bidding farewell to that hour of sleep in March and waiting months to welcome that hour back in November. But while the U.S. Senate voted this week to eliminate that biannual clock change in the Sunshine Protection Act, it would also come with something sleep experts don’t want to see happen – making daylight saving time permanent in 2023. Supporters of living in daylight saving time year-round say it would give children more time to play outside in the afternoon and it would be good for the economy. But many physicians are urging lawmakers to make standard time a permanent thing, to allow our bodies’ internal clocks to be aligned with the timing of the sun. Wayne State University professor Dr. James Rowley, who also serves as the medical director at Detroit Receiving Hospital’s Sleep Disorder Center and as an officer with the American Academy of Sleep Medicine, firmly believes we should be on permanent standard time. “It’s well known that the changes in March result in increases in cardiovascular disease, heart attack, stroke, and driving accidents. And there are some subtle changes even when we go backwards again in the fall,” he said, noting that if lawmakers adopt a uniform daylight saving time, Michiganders won’t have sunlight until 9 a.m. in the winter. “There’s good evidence that we need sunshine in the morning to be awake during the day.” 

By Logan Tesmer  Dr. Hilary Marusak is the director of Wayne State University’s THINK lab and an assistant professor at the Wayne State University School of Medicine. THINK is an acronym for Trauma History Investigation of Neurodevelopment in Kids. The THINK lab studies brain development in children and adolescents and the impacts of environmental stress on the brain, as well as anxiety and PTSD. These traumas can be found in interpersonal forms, such as violence, as well as medical-related traumas from a cancer diagnosis or treatment. The lab’s work also targets the recovery from these traumas through exercise, meditation, or pharmaceuticals. Dr. Marusak joins for a segment of Community Connect to discuss her love of science, getting more girls into the industry, and how the THINK lab helps children in the community. “If you work with kids, I think you share this idea that if you intervene early, you can really change the course of that kid’s life. The brain is changing so rapidly and dynamically during that time, so it’s much easier to take advantage of that brain plasticity and get kids on a better chart for the rest of their life,” said Dr. Marusak.  

By Katherine Lee  Sleep apnea is a common and potentially serious sleep disorder. It causes you to stop breathing temporarily and occurs repeatedly during sleep. These pauses in breathing can happen as many as hundreds of times in one night. Your brain registers what’s going on and wakes you up, though sometimes only partially or for such short moments you may not even realize the arousals. Because the primary symptoms of sleep apnea occur during sleep, many people with sleep apnea may not even realize it’s happening. Sleep apnea can take a toll on the body and lead to a number of negative physical, cognitive, emotional, and behavioral effects, including inflammation throughout the body caused by chronic cycles of accelerated heart rate and increased blood pressure. “There’s good evidence that having obstructive sleep apnea puts you at increased risk for high blood pressure, stroke, heart disease, and death,” said James Rowley, professor of medicine and division chief of pulmonary, critical care and sleep medicine at Wayne State University School of Medicine.  

By Arash Javanbakht  Arash Javanbakht, associate professor of psychiatry and director of the Stress, Trauma, and Anxiety Research Clinic at Wayne State University, authored an article about the psychological wounds caused by the Russian invasion of Ukraine that could linger for generations. Javanbakht outlines research findings that human-caused catastrophes have a higher likelihood than natural disasters of causing severe consequences including PTSD, depression, and anxiety. Children are specifically vulnerable, and trauma can be transferred from parents to their current and future children. “Putting human suffering into numbers as I’ve done here is not in any way meant to convert a human tragedy into a cold statistical concept,” Javanbakht wrote. “The purpose is to show the enormous impact of such calamity. Each life or livelihood lost is a tragedy in and of itself.”  

As Michigan continues to recover from the latest COVID-19 surge, state health departments are beginning to ease mask recommendations for indoor public settings. The new guidance now allows individual businesses and schools to decide whether or not their establishment requires masks. According to the state, no immediate resurgence of the virus is predicted so they’re calling this phase of the pandemic “recovery.” Dr. Teena Chopra, professor of infectious diseases at Wayne State University, says these relaxed rules mean individuals need to be flexible and more aware of their own risks. “People who are at higher risk…if they’re going to be in a setting where it’s going to be crowded, they should continue masking,” she said.  

COVID-19 vaccines have been instrumental in the fight against the pandemic. Life hasn’t returned to normal yet, but vaccines have been highly effective against severe disease and death, saving countless lives and helping our already strained hospital systems from being overwhelmed. Researchers are already working on the next generation of vaccines in hopes of fighting new strains of the virus and making it easier to deliver vaccines at home and around the world. Nearly 5.9 million Michiganders are fully vaccinated, but as we have seen, variants can present major setbacks. The next generation of vaccines could change how we deliver the shot. Nasal sprays and pills would make distribution easier, but those versions may not be available this year. “We are already hearing about technologically advanced vaccines that can help us with challenges and barriers and storage,” said Dr. Teena Chopra, a professor of infectious disease at Wayne State University. She says easier storage will be key to reaching rural areas and less developed nations, a vital step in stopping viral variants. Dr. Chopra says for now, we need to focus on making current COVID-19 treatments more available, and, in addition to technological advancement, social innovation. “…the U.S. has one of the lowest vaccine uptakes, and I think largely it is due to the lack of trust that our population has. So, I think we need to work on that trust component.,” she said.  

To be more successful when it comes to weight loss goals, the secret may be a good night's sleep. New research suggests that an extra hour of sleep every night could help sleep-deprived people who are overweight eat 270 fewer calories per day without even trying. That change translates to nearly nine pounds of weight loss over a year. The study is not the first to connect sleep with eating patterns. Despite a growing body of evidence suggesting that adequate sleep helps people stick to a healthy diet, sleep still doesn't tend to be part of weight loss conversations - even those that happen between doctors and their patients. But that's changing, says Dr. James Rowley, a professor of critical care and sleep medicine at Wayne State University. "For many years, sleep just was not considered part of the 'equation' so to speak," Rowley said. "Now there is growing recognition that sleep needs to be considered as an important component of cardiovascular health, metabolic health, and exercise and eating. It's clear that adequate sleep is important for overall health." Dr. Rowley said he's already started to recommend more sleep to aid in weight loss and weight maintenance in his own practice, and that this new research is an important piece of the puzzle that reinforces the effect improved sleep quantity can have on calorie consumption.  

As co-directors of the Wayne State University Center for Emerging Infectious Diseases, Marcus Zervos, M.D., Teena Chopra, M.D., M.P.H., Paul Kilgore, M.D., M.P.H., and Matthew Seeger, Ph.D, share their perspectives on lessons learned from the COVID-19 pandemic. The experts discuss parallels between previous pandemics, exacerbated health disparities, a lack of response and resource coordination, the dangers of misinformation, and ways the public health system can better prepare for future pandemics. Together, the co-directors assert that if we learn from this pandemic, our post-COVID-19 world will be more resilient, health disparities will be reduced, and our public health system will become stronger.  

By Michelle R. Smith  Anti-vaccine activist Robert F. Kennedy Jr. made “deeply offensive” comments when he suggested things are worse for people today than they were for Anne Frank, the teenager who died in a Nazi concentration camp after hiding with her family in a secret annex in an Amsterdam house for two years, several Jewish advocacy and Holocaust remembrance groups said. Kennedy has invoked the specter of Nazis and the Holocaust in his work to sow doubts about vaccines and agitate against public health efforts to bring the pandemic under control, such as requiring masks or vaccine mandates. Although Kennedy has previously apologized for his use of such tactics, Dr. David Gorski, a cancer surgeon at Wayne State University School of Medicine and a critic of the anti-vaccine movement who has tracked Kennedy’s rhetoric for over 15 years, says his continued use of such comparisons indicates “he means it.” Gorski said the language demonstrates one of the ways Kennedy likes to connect with his audience: buttering them up by portraying them as going against the flow and smarter than everyone else. “If vaccine mandates are totalitarian like Nazis and the Soviet Union and that sort of thing, what does that make the anti-vaxxers? They’re brave freedom fighters,” Gorski said. “There’s flattery in those analogies.”  

The first case of Flurona has been reported in the United States. Doctors say the co-infections are a mix between Influenza and Covid, where patients will show positive results for both viruses. Health care professionals say the best defense is the vaccine, in addition to wearing masks and social distancing. Doctors recommend surgical masks, like an N-95, which provides the best protection, unlike cloth masks that don’t guard against the transmission of respiratory fluids. Flurona symptoms include fever, cough, fatigue, runny nose, body aches and sore throat. “Every year we get the annual Flu shot and it is still important this year, especially when we know that we have a very super-infectious variant circulating and we don’t want to get co-infections with Flu and Omicron,” said Wayne State University professor of infectious diseases Dr. Teena Chopra, MD, MPH. “Respiratory viruses have a very similar way of transmission. You know influenza transmission is through droplet infections, whereas Omicron, which is coronavirus, we know to be airborne and highly infectious.”  

The Michigan Department of Health and Human Services has awarded $4.3 million to the Wayne State University Center for Emerging and Infectious Diseases. The funds will increase lab facilities to collect and analyze genomic data to address emerging infectious disease threats and enhance the state’s ability to respond to those threats. The funding, part of $18.5 million provided to WSU, Michigan Tech University, Michigan State University and the University of Michigan, will increase infectious disease sequencing capacity in the state, beginning with the COVID-19 virus. “COVID-19 has clearly demonstrated that we need more lab capacity in the state, and specifically in southeast Michigan,” said Marcus Zervos, M.D., co-director of the WSU Center for Emerging and Infectious Diseases and COVID-19 advisor to the City of Detroit. “We must be prepared for the next mutation or the next disease.” 

As omicron COVID-19 cases skyrocket in Michigan, hospitalizations are increasing as well – although at a far slower rate – and prompting concerns about capacity. Even though the variant is mild for most, the wave has increased hospital admissions statewide by 400 in one week, a 10% rise, while forcing hundreds of critical health care workers to quarantine. Just a few weeks after hospitalizations dropped from a peak of nearly 4,800 patients, the health care system is girding again for another COVID-19 crunch, which may be less lethal but could tax its ability to provide care. On Monday the state reported 61,235 new infections for the past five days, an average of 12,247. For the past week, the daily average of 12,442 is up 65% from the previous week’s average of 7,533 daily cases. Dr. Teena Chopra, director of the Center for Emerging and Infectious Diseases and a professor at Wayne State University School of Medicine works with local hospitals and said that although a smaller fraction of those who get infected are requiring hospital care, the previously unseen scale of infections is still leading to hundreds of people sick enough to require a hospital visit, especially in Detroit which has one of the lowest vaccination rates in the state. “The sheer numbers are so huge, the hospitals are getting overwhelmed,” Dr. Chopra said.

By Darren Cunningham  The interest in keeping up with COVID and its variants varies from person to person. Some opt to just follow the protocols; others want to know the science behind the severity and transmissibility. Scientists say the newest strain, omicron, spreads quicker than delta but is less severe. Doctors, including Dr. Phillip Levy, a professor of emergency medicine and researcher at Wayne State University, said it's important to keep in mind most of the studies on omicron so far have been conducted in South Africa, a different population with younger people being infected. “So, when you say, ‘could it be more severe?’ It wouldn’t be more severe because omicron itself becomes something different. I mean that could happen, and it may create a new severe variant which would have a new Greek alphabet naming structure. But omicron itself, we still just don’t know what it’s going to do when it hits our population,” said Dr. Levy.

Wayne Health has been hosting drive-through clinics on Mack Avenue to provide monoclonal antibody treatments, which can be the difference between life and death for those most vulnerable to severe illness from COVID-19. But amid Michigan’s worst-yet coronavirus surge, there’s not enough supply of monoclonal antibodies nor are there enough health care workers to administer them. “COVID testing and vaccinations remain our pillar, but we’re also very heavily engaged in monoclonal antibody infusions, which are a great way to prevent people who do contract COVID – particularly high-risk individuals – from getting sick to the point where they require hospitalization or at risk for dying,” said Dr. Phillip Levy, professor of emergency at Wayne State University, chief innovation officer for Wayne Health, and assistant vice president for research. Levy said when the virus attacks the body, it’s like an internal war in which coronavirus particles are the invaders pitted against the antibody soldiers a person’s immune system has called to defend it. “The monoclonal antibodies basically are a pharmaceutical version of the antibodies your body would produce anyway to fight off the virus. And by taking these antibodies and sort of bolstering your natural immune system, you get more soldiers, more fighters against the virus,” said Dr. Levy.  

Hilary Marusak, assistant professor of psychiatry and behavioral neurosciences at Wayne State University, wrote an article sharing an explanation of the impact exercise has on the body’s natural cannabinoids and the associated benefits for mental health and stress relief. The “runner’s high” has long been attributed to endorphins, but research from Marusak’s lab found that exercise reliably increases levels of the body’s endocannabinoids – which are molecules that work to maintain balance in the brain and body – in a process called “homeostasis.” This natural chemical boost may better explain some of the beneficial effects of exercise on brain and body.  

Santa made a recent visit to Detroit to spread holiday cheer and help encourage community members to get vaccinated. A Wayne Health Mobile Unit provided COVID-19 vaccines, as well as flu shots and other screenings, at the pop-up clinic at Saunders Memorial A.M.E. Church. The event also featured ice sculptures and food.  

Scientists at the John A. Moran Eye Center at the University of Utah have discovered a new type of nerve cell, or neuron, in the retina. The discovery marks a notable development for the field as scientists work toward a better understanding of the central nervous system by identifying all classes of neurons and their connections. The research team named their discovery the Campana cell after its shape, which resembles a hand bell. The published research study, “An uncommon neuronal class conveys visual signals from rods and cones to retinal ganglion cells,” was authored by Tushar Ganjawala, a Ph.D. student in the Wayne State University School of Medicine, and co-authors Brent K Young, Charu Ramakrishnan, Ping Wang, Karl Deisseroth, and Ning Tian. The work was supported by an NIH Core Grant, and an Unrestricted Grant from Research to Prevent Blindness, New York, NY, to the Department of Ophthalmology & Visual Sciences, University of Utah, and the Department of Ophthalmology of Wayne State University School of Medicine; additional support was provided by the Ligon Research Center of Vision, Kresge Eye Institute, and the Dryer Foundation.