Wayne State researcher calls for dramatic shift In cancer research
For decades, cancer has been believed to be caused by a sequential accumulation of common gene mutations, with the identification, characterization and targeting of common genetic alterations and their defined pathways dominating the field. Henry Heng, associate professor in Wayne State's Center for Molecular Medicine and Genetics, is challenging this notion, however, with evidence that the general mechanism of cancer occurs at the level of the genome, not the gene. Heng published a study in a recent edition of the Journal of Cellular Biochemistry that represents an important illustration of the evolutionary mechanism of cancer. "Considering cancer as an evolutionary process is vital to both basic research and clinical applications," Heng said. "Unfortunately, most previous efforts have focused on individual cancer genes, which represent only a small part of the evolutionary story of cancer. A growing body of evidence suggests that no distinguishable pattern can be discerned from single gene studies. Instead, it appears that finding a general mechanism will require us looking to the system as a whole -- the genome."
http://www.wwj.com/Wayne-State-Researcher-Calls-For-Dramatic-Shift-In/7408668