Arash Javanbakht, associate professor of psychiatry, wrote an article for The Conversation about the benefits of exercise on the brain. “As with many other physicians, recommending physical activity to patients was just a doctor chore for me – until a few years ago. That was because I myself was not very active. Over the years, as I picked up boxing and became more active, I got firsthand experience of positive impacts on my mind. I also started researching the effects of dance and movement therapies on trauma and anxiety in refugee children, and I learned a lot more about the neurobiology of exercise. I am a psychiatrist and neuroscientist researching the neurobiology of anxiety and how our interventions change the brain. I have begun to think of prescribing exercise as telling patients to take their “exercise pills.” Now knowing the importance of exercising, almost all my patients commit to some level of exercise, and I have seen how it benefits several areas of their life and livelihood.

Dr. Paul Kilgore is an Associate Professor and Director of Research at Wayne State University’s College of Pharmacy and Health Science. He’s also a principal investigator at Henry Ford Health System and an expert in vaccine research. As the country hit 500,000 deaths from COVID earlier this week, Kilgore says that we still have a lot of work to do. “There’s no doubt about it, the vaccine will be an important tool but not the only one,” says Kilgore. He adds that it will continue to be crucial that people wear masks and practice distancing in the months ahead. He also points to other countries, including Korea, where mask wearing as a way of minimizing disease transmission is a normal part of life and would be beneficial here in the United States as well. ”We need to think very carefully about how we adopt mask wearing in this country as a permanent activity… that can really help when reducing transmission,” says Kilgore. As far as the outlook for the next several months here in Michigan, Kilgore says that he thinks ”what we’ll see as (weather warms up) is potential reduction in transmission but… if variants are causing easier transmission we will still need to be very vigilant about masking, distancing and getting vaccinated as soon as possible.” 

Dr. Teena Chopra, a professor of infectious diseases at Wayne State University in Detroit, says the situation is starting to improve.

After giving his two cents at the White House, Detroit Mayor Mike Duggan returns to the city to try to steer it through the pandemic. Duggan talked about the challenges of the COVID-19 vaccine on Flashpoint. Then the “other” pandemic -- the mental health struggles of young people after a year of COVID-19. From the beginning, we’ve wondered about the toll the pandemic has been taking on all of us from a mental health standpoint. Studies are now making clear what many feared, that it’s having a deep and damaging impact on teenagers. There was a discussion on the issue with two health professionals including pediatrician Dr. Lynn Smitherman from Wayne State University and Mary Beth Garvey, a family therapist from Grosse Pointe.

Dr. Herbert Smitherman, general internist at the Detroit Medical Center and vice dean of Diversity and Community Affairs at the Wayne State University School of Medicine, has been a practicing physician in Detroit for 33 years. Smitherman said he has met with several Black patients who don’t trust the COVID-19 vaccine or the health care system itself. He believes that can change if there are more Black doctors. “The race of the provider and having people that look like you, understand you, understand your concerns and your culture are very important to helping you receive needed care,” Smitherman said. A 2018 study done in Oakland, California, found that increasing the number of Black doctors could reduce the Black-white male gap in cardiovascular mortality by 19 percent. A 2016 study found that Black men and women in the U.S. have a life expectancy that was, respectively, 4.4 and 2.8 years shorter than white men and women. But Smitherman cautions that efforts to increase the number of Black doctors cannot be the only solution. “The mistrust was not created by Black physicians. It was structural racism and systemic racism within a health care system that created that mistrust, not Black physicians, but by non-Black physicians,” he said. Smitherman pointed out that issues such as where the vaccine is distributed, the times of day it’s offered, and the method for scheduling a vaccine appointment are all potential complications for the average Detroiter. He said figuring out solutions is all about having a diverse group of decision-makers at the table. “If you aren't having people of color represented in your real strategy setting and planning for vaccine distribution, we're not going to get where we need to get,” he said.

Wayne County Chief Judge Timothy Kenny has been working to stop the spread of COVID-19. Through bond reductions and early releases, he's helped to send home over 400 inmates since last March. Close quarters, limited PPE, a high population due to mandatory sentencing guidelines and old buildings with poor ventilation have conspired to make correction facilities hotbeds for COVID-19. Michigan's prison system — the Michigan Department of Corrections — has gotten the most attention around this. Since the start of the pandemic, more than 135 inmates within the MDOC have died from COVID-19. One in two of the department's inmates have tested positive since March. But jails are battling many of the same issues. In addition to Judge Kenny — and others within the Third Circuit Court — pushing to release inmates, the jail has also ramped up its testing protocol, per Sheryl Kubiak, dean of Wayne State University's School of Social Work. Kubiak has worked with Chief of Jails Robert Dunlap to create a testing and contract tracing plan. "When COVID hit and we knew that the jail was in such trouble — we made a call and said what can we do to help," said Kubiak, who explained that at the time, they were just learning that people could have no symptoms and still transmit COVID-19. Working with Wayne State University's Medical School, they did a series of mass testing to find out what the prevalence rate was, decide who to isolate and make future plans.

After the left ventricle of the heart contracts, it must relax efficiently to prepare to refill and supply the body with blood on the next beat.  An increasing number of patients — including nearly all patients with heart failure — suffer from impaired relaxation, which is part of a clinical syndrome known as diastolic dysfunction. Currently, treatments for impaired relaxation do not exist. A team of Wayne State University School of Medicine researchers led by Charles Chung, Ph.D., assistant professor of physiology, recently received a $1,894,271 grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to address the critical need for new drug targets and diagnostic indexes for diastolic dysfunction using novel biomechanical tests that ultimately can be translated into clinical practice. According to Chung, the project was inspired by his research team’s finding that how quickly the heart’s muscle moves is directly related to how fast the muscle can relax. The project will use unique experiments and imaging techniques to link mechanical properties of the heart with models of heart failure that occur in patients. “My lab’s main research focus is to understand how the heart muscle moves at the end of contraction and how this motion can speed up the force decline, or relaxation, of the muscle,” said Chung. “Major proteins in muscles called myosin, actin and titin control the force of each beat. When the heart muscle contracts, myosin binds to actin to generate force. Our lab is trying to determine if motion — and how fast the motion occurs — makes myosin let go of actin faster and make the muscle relax faster.” 

Racial health disparities were known long before COVID-19 was a blip on a world news briefing in the U.S. Former U.S. Secretary of Health and Human Services Margaret Heckler wrote in a 1985 report from her Task Force on Black and Minority Health that such disparities have been present in federal records ever since accurate federal record-keeping began. And Heckler’s report, the first comprehensive study of racial and ethnic minority health by the U.S. government, looked at two years of averages and determined about 60,000 deaths, or 42.3% of deaths, of Black people under the age of 70 were considered “excess.” The report also determined six key factors, including cardiovascular disease, cancer, diabetes, and homicide, that drove higher death rates among Black people and it made recommendations to address the concerns, such as training in the medical community on cultural sensitivity, more education, and the gathering of more data. There hasn’t been a ton of progress since then, said Wayne State University President Dr. M. Roy Wilson. Wilson served as a deputy director at the National Institute on Minority Health and Health Disparities under the National Institutes of Health and is a member of the Michigan Coronavirus Task Force on Racial Disparities. “We understand a little bit more now about what some of the underlying issues are, but there are intractable issues …  some of them are things like education and income and other things which are bigger societal problems,” he said. COVID-19, with its fast onset, simply showed the results of health disparities faster than all the other illnesses health disparities cause, Wilson said. One thing isn’t talked about enough, said Wilson. That's how Michigan responded when the racial gaps in COVID-19 deaths were identified. The success has been “remarkable,” he said.

Wayne State University School of Medicine researchers have reported that zinc supplements for men and women attempting to conceive either naturally or through assisted reproduction during the COVID-19 pandemic may prevent mitochondrial damage in young egg and sperm cells, as well as enhance immunity against the virus. In “Potential Role of Zinc in the COVID-19 Disease Process and its Probable Impact on Reproduction,” published in Reproductive Sciences, Husam Abu-Soud, Ph.D., associate professor of Obstetrics and Gynecology and the C.S. Mott Center for Growth and Development, said that in addition to benefiting couples attempting to conceive during the pandemic, zinc supplementation of up to a maximum of 50 mg per day for all adults could be beneficial in enhancing immunity and fighting the viral disease process of COVID-19. He also noted that zinc can be beneficial to the general population in enhancing immunity and fighting the viral disease process.

Children have been less impacted by COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SAR-CoV-2) than adults. But some children diagnosed with SARS-CoV-2 have experienced severe illnesses, including Multisystem Inflammatory Syndrome (MIS-C) and respiratory failure; nearly 80% of children with MIS-C become critically ill with a 2 to 4% mortality rate. Currently, there are no methods to discern the spectrum of the disease’s severity and predict which children with SARS-CoV-2 exposure will develop severe illness, including MIS-C. Because of this, there is an urgent need to develop a diagnostic modality to distinguish the varying phenotypes of disease and risk stratify disease. To prevent children from becoming critically ill from SARS-CoV-2, a team of Wayne State University researchers led by Dongxiao Zhu, Ph.D., associate professor of computer science in the College of Engineering, are developing an artificial intelligence (AI) model to aid in the early detection of severe SARS-CoV2 illness in children.

The Michigan Department of Health and Human Services (MDHHS) is partnering with Wayne State University and Wayne Health to provide mobile COVID-19 testing. The partnership comes in an effort to reach more Michiganders in need of COVID-19 testing and other public health services. This new program allows three mobile units to move between sites and serve communities at the highest risk. Locations are chosen in part to help address racial and ethnic disparities that had existed prior to the pandemic and were exacerbated by the virus – a focus of the Racial Disparities Task Force. Wayne Health’s Mobile Health Unit offers an array of health care screenings, including COVID testing, flu shots, blood pressure screening, HIV testing and on-site referrals for public benefit programs such as Medicaid and unemployment assistance and emergency food and shelter services addressing social determinants. “Partnering with the state will expand our efforts to bring these vital services to more Michigan residents who need them,” said Phillip Levy, M.D., M.P.H., who leads the Mobile COVID Testing Program for Wayne Health and is WSU’s assistant vice president for Translational Sciences and Clinical Research Innovation. “This work is a key element of who we are as a university and as a practice group. Meeting people and providing services where they live is critical not only to containing the COVID-19 pandemic, it is essential to improving health in general.” 

While the number of immigrants from Arab countries to the United States has steadily increased over the past several years, family and child health research on this population remains scarce. To address this disparity, Dalia Khalil, Ph.D., RN, assistant professor in Wayne State University's College of Nursing, was recently awarded a two-year, $161,451 grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health. Khalil and her team will expand on her previous research on immigrant Arab American parents and families.

As the initial priority groups are being offered a COVID-19 vaccine in the U.S., one population in particular faces a difficult decision: Pregnant people who are health care personnel or essential workers—categories that are eligible for the early phases of the vaccination program—“may choose to be vaccinated,” according to the latest official guidance from the Centers for Disease Control and Prevention. The problem is that there are scant data available on the safety of COVID-19 vaccines in pregnant individuals. They were not included in the clinical trials, as has historically been the case with most vaccines and drugs. For many years, it was believed that pregnancy was a state of immunologic weakness. The fact that pregnant individuals died more from diseases such as influenza was attributed to this state. More recently, it became clear that immunologic changes in pregnancy were much more complex than that. “They were not dying because they were immunosuppressed,” says Gil Mor, scientific director of the C. S. Mott Center for Human Growth and Development at Wayne State University. “They were dying because their immune system was so strong and activated that they produced a massive inflammation that killed them.” Mor, who is an expert in the immunology of pregnancy, says there are several mechanisms to maintain the delicate balance between too much and too little inflammation during that state. If this balance is not maintained for any reason, the risk of severe COVID-19 symptoms rises.

Wayne State University’s Dr. Paul Kilgore discusses the latest developments around COVID-19 and what Michiganders can do to remain vigilant in slowing the spread of the virus. Many people are hopeful that the COVID vaccine is a light at the end of a nearly year-long tunnel that has taken Americans very far away from what life was like pre-pandemic. But now, as Michigan and other states are struggling to get the vaccine distributed, there’s an even bigger obstacle: The emergence of several new variants of the coronavirus. “The virus is actually changing its genetic code. It’s changing over time. All viruses do that, and we expected it from the beginning,” says Kilgore, associate professor and director of research at Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences. He’s also the principal investigator at Henry Ford Health System’s testing of Moderna’s vaccine trial. As far as the severity of COVID-19 symptoms in the new variants, Kilgore says there is some research indicating that these mutations could create more complicated cases of the virus. In looking ahead to how these new variants could impact the future of life in Michigan and throughout the country, Kilgore says, “I think there’s a chance this gets worse before it gets better in the next several weeks.”

The National Institutes of Health is supporting a Wayne State University School of Medicine physician-researcher’s work at preventing and treating cerebral palsy in the form of two new five-year R01 grants worth a collective $5.59 million. The principal investigator on both projects is Sidhartha Tan, M.D., professor and co-division chief of Neonatology in the Department of Pediatrics. Cerebral palsy is a group of disorders that affect a person’s ability to move and maintain balance and posture. CP is the most common motor disability in childhood, caused by abnormal brain development or damage to the developing brain that affects a person’s ability to control his or her muscles. Tan obtained his first R01 last May for “Potent Neuronal Nitric Oxide Synthase Inhibition for Prevention of Cerebral Palsy,” which will provide $2,393,590 over the half-decade award period to test new, promising drugs aimed at a preventive cure for the condition. “These are new drugs aimed at brain condition called neuronal nitric oxide synthase. New information about how these drugs act, how they affect brain cells and how effective they are in an animal model of cerebral palsy will be very valuable for future translation to clinical use in humans throughout the world,” Tan said. His second, a multiple principal investigator award launched Dec. 15, is “Probing Role of Tetrahydrobiopterin in Cerebral Palsy by Using Transgenic Rabbits.” The grant will provide $3,197,644 in funding over five years to explore whether an essential enzyme co-factor is involved in brain injury before birth. The cellular and genetic basis of brain regional injury will be investigated using an animal model in which genes have been altered by genetic engineering methods, as well as advanced methods of magnetic resonance imaging.

A small, liquid-filled sensor can continuously and accurately measure heart and lung sounds, detecting cardiac problems or shortness of breath at an early stage, something which could warn heart failure patients of health deterioration and also help pick up early signs of infections such as Covid-19. Many of us own smart watches or fitness trackers, a large number of which now include heart rate monitors. However, while their accuracy has improved, they offer fairly limited information about heart health. They mostly measure heart rate by shining a green light through the skin, a method called photoplethysmography, which controversially works much better on lighter rather than darker skin. Heart sounds, such as those heard by a stethoscope, can give a more accurate picture of heart health as they can pick up inconsistencies of rhythm as well as rate. But have been historically harder to track using a wearable device. To try and get round this problem, Yong Xu, a professor of electrical and computer engineering at Wayne State University, and his team have developed a small flexible sensor that can be worn continuously on the chest to measure heart and lung sounds. “Heart and respiration activities offer pivotal physiological and pathological information through mechano-acoustic signals. Continuous monitoring of these signals has the potential to significantly improve the diagnosis and management of many cardiovascular and respiratory diseases,” emphasizes Xu.

Today, small groups of scientists, psychologists and other medical professionals are looking at psychedelics once again for the claims that they can be beneficial for those suffering from severe mental health issues. The movement for decriminalization has focused primarily on those efforts, although some proponents also advocate for those who choose to safely use psychedelics recreationally. Susanne Brummelte, professor of psychology at Wayne State University, said today the study and understanding of psychedelics is “an emerging field because it was illegal. They've been Schedule I drugs, so it's very difficult to do research, though there is beginning to be some research on the medical benefits of LSD, and they're getting some idea that with a guided trip it can help with depression and other issues.” Scott Bowen, professor and chair of the department of psychology at Wayne State University, said, “Decriminalization allows for some research to study depression, anxiety, mood enhancement. The question is, does it really happen? Unless there's a placebo – a negative – you don't have a scientific study to determine efficacy. There's a lot of anecdotal information that can be attributed to the placebo effect.” Bowen and Brummelte believe there needs to be more research on the medical benefits of microdosing, as well. “LSD is a powerful drug. It affects your serotonin receptors, so it will definitely change your brain,” said Bowen. “The question is, is that happening with microdosing? There are a lot of unknowns. It's just so new. LSD by itself is the most potent – you just need a teeny amount, but it is also the most effective.”

Wayne State University’s School of Medicine needs people to roll up their sleeves for research’s sake. The school is part of a nationwide clinical trial of a COVID-19 vaccine made by Novavax, Inc. Phase 3 of the trial will help scientists determine whether it’s effective at preventing infection. Dr. Elizabeth Secord is heading up WSU’s involvement in the trial. She says her team needs about 300 volunteers. “Two-thirds will get the vaccine, one third will get a placebo,” she says. “We can compare rates of COVID, look at antibodies and see the effectiveness of the vaccine.” At first, researchers wanted a large number of higher-risk candidates, such as people 65 and older, individuals with underlying health conditions and people of color. They can still enroll, but now that many older people are eligible to receive the Pfizer or Moderna vaccines, Wayne State is actively seeking younger volunteers for the study. “People who are, for example, 60, 50, 40, even in their 20s who are not likely to get a vaccine for several months,” Secord says. “It would be good for them to consider entering such a trial.” Unlike the Pfizer and Moderna vaccines, the Novavax COVID-19 vaccine does not use messenger RNA. Secord says she hopes that will encourage people to join the clinical trial, though she stresses that concerns about mRNA are unfounded, noting that she has already been vaccinated. “I think that this vaccine will be safe, the other vaccines are safe, and that people should take what they can get as soon as they can get it,” she says. If the Novavax vaccine passes its trials, Secord says she hopes it will be approved for emergency use within six months.

Wayne State University President M. Roy Wilson, Michigan State President Samuel L. Stanley Jr.,  and University of Michigan President Mark S. Schlissel wrote an op-ed regarding the COVID-19 vaccine as a means to stop the pandemic. “As presidents of the three major public research universities that make up Michigan’s University Research Corridor — Michigan State University, the University of Michigan and Wayne State University — we’ve been on the front lines of battling the COVID-19 pandemic. URC researchers have worked to develop tests, treat the virus and create vaccines. We’re training thousands of physicians, nurses and other health care workers in dealing with the virus. We’re helping educators, business owners and government officials deal with the challenges of COVID-19. As COVID-19 case counts continue to rise across the United States, getting everyone possible vaccinated as soon as enough doses are available is vital to stopping this pandemic, reviving our national economy and getting children and college students back to in-person school. The alternative is what we have now: high caseloads that are overwhelming our hospitals and health care workers, and millions of students able to attend classes only online. Our economy will continue to falter and layoffs will increase as the coronavirus makes it unsafe to shop and dine as we normally do. Family gatherings and large meetings will remain off limits or, if held, become potential superspreader events.”

Mustapha Al-shorbaji is a nursing student at Wayne State University. He sits in the lobby of the Campus Health Center with a black mask on, waiting to get a COVID-19 vaccine. “As soon as I was presented the opportunity, I took the first appointment I could get to come here,” says Al-shorbaji. Wayne State University began offering the vaccine to medical students and faculty with clinical rotations on January 7. That’s how Al-shorbaji found himself among the first people in the country to be given the chance to be inoculated against the coronavirus. In addition to frontline health care workers, vaccinations throughout Michigan have been given to some people in long-term care facilities, police officers, bus drivers, K-12 teachers, postal workers, people over the age of 65 and others. Eligibility varies depending on where people live, work, or go to the doctor. As of January 19, according to data from the Michigan Department of Health and Human Services, about 75,800 people in Michigan have received at least the first dose of the vaccine. In a state that’s estimated to have roughly 8 million people age 16 and up (according to the US Census Bureau’s American Community Survey), that means less than 1% of the population has been vaccinated.