DETROIT – A team of researchers from Wayne State University received a nearly $2.7 million government grant under the auspices of the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health for the study, “Infusion device optimization by addressing root causes of the inflammatory response.”
Although insulin infusion systems for diabetes continue to improve, their lifespan is limited to three days, as the device insertion itself leads to inflammation and localized injury. Moreover, the preservatives used to stabilize insulin are also tissue toxic.
“All of the commercially available insulin formulations contain phenolic preservatives that prolong insulin shelf life but also cause tissue injury,” stated Ulrike Klueh, Ph.D., associate professor of biomedical engineering in Wayne State University’s College of Engineering. “Our team is focused on methods that reduce these preservatives’ tissue toxicity.”
Klueh and her research team reported that these devices induce mast cell activation and subsequent leukocyte recruitment, which initiates inflammation. Thus, overcoming these tissue toxic reactions represents a significant advancement in the goal to achieve normal blood sugar levels in diabetic patients.
The award number for this grant is DK129681. For more information, visit reporter.nih.gov/search/AfHuVJurFk-jAdeG_kjvCg/project-details/10443241#details.
About Wayne State University: Wayne State University is one of the nation’s pre-eminent public research universities in an urban setting. Through its multidisciplinary approach to research and education, and its ongoing collaboration with government, industry and other institutions, the university seeks to enhance economic growth and improve the quality of life in the city of Detroit, state of Michigan and throughout the world. For more information about research at Wayne State University, visit research.wayne.edu.
Related articles
Accelerate mobility
-
Provost announces 2024-25 Academic Leadership Academy cohort
-
Wayne State School of Social Work receives more than $1 million to support the next generation of Michigan’s behavioral health social workers
-
Wayne State, Rocket Companies and Grow Detroit’s Young Talent engage and educate next generation of technology leaders with Tech On-Ramps program
-
Wayne State leaders’ research affirms transformative value of college education, importance of equitable access
College to Career
-
Alumnus aspires to move from the mound to management after earning master’s in sports administration from the Wayne State University College of Education
-
The power of a practicum: Applied behavior analysis program helps alumna find her calling, build her confidence and advance her career
-
Internship put exercise and sport science alumna on path to career in emergency medicine
-
Lyndsey Crum is new assistant vice president of Alumni Relations, executive director of WSU Alumni Association
Fuel innovation
-
Detroit researchers find new clues in causes of vision loss in various ocular diseases that may lead to new treatments
-
Wayne State named 2024 APLU Innovation & Economic Prosperity Awards finalist
-
Wayne State, Rocket Companies and Grow Detroit’s Young Talent engage and educate next generation of technology leaders with Tech On-Ramps program
-
President Espy talks economic development, higher education with MSU, UM leaders
Empower health
-
Wayne State experts raise alarm on social media’s role in adolescent mental health
-
Wayne State research project seeks answers to behind armor blunt trauma injuries
-
The power of a practicum: Applied behavior analysis program helps alumna find her calling, build her confidence and advance her career
-
Internship put exercise and sport science alumna on path to career in emergency medicine
Public Health
-
V Efua Prince explores urban health challenges in new book ‘Kin’ amid ongoing research on addiction and mental health
-
Riding with the Wayne Mobile Health Unit
-
NIH funds critical center in Detroit to lead efforts to investigate and mitigate health impacts of community-voiced chemical and non-chemical stressors
-
Wayne State University experts warn of potential threats due to low vaccination rates in Michigan; stress importance of immunization