DETROIT – A team of researchers from Wayne State University received a nearly $2.7 million government grant under the auspices of the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health for the study, “Infusion device optimization by addressing root causes of the inflammatory response.”
Although insulin infusion systems for diabetes continue to improve, their lifespan is limited to three days, as the device insertion itself leads to inflammation and localized injury. Moreover, the preservatives used to stabilize insulin are also tissue toxic.
“All of the commercially available insulin formulations contain phenolic preservatives that prolong insulin shelf life but also cause tissue injury,” stated Ulrike Klueh, Ph.D., associate professor of biomedical engineering in Wayne State University’s College of Engineering. “Our team is focused on methods that reduce these preservatives’ tissue toxicity.”
Klueh and her research team reported that these devices induce mast cell activation and subsequent leukocyte recruitment, which initiates inflammation. Thus, overcoming these tissue toxic reactions represents a significant advancement in the goal to achieve normal blood sugar levels in diabetic patients.
The award number for this grant is DK129681. For more information, visit reporter.nih.gov/search/AfHuVJurFk-jAdeG_kjvCg/project-details/10443241#details.
About Wayne State University: Wayne State University is one of the nation’s pre-eminent public research universities in an urban setting. Through its multidisciplinary approach to research and education, and its ongoing collaboration with government, industry and other institutions, the university seeks to enhance economic growth and improve the quality of life in the city of Detroit, state of Michigan and throughout the world. For more information about research at Wayne State University, visit research.wayne.edu.
Related articles
Accelerate mobility
-
Wayne State leaders’ research affirms transformative value of college education, importance of equitable access
-
Wayne State Across the Globe: Summer Research Map 2024
-
Professor inspires community college students to redirect academic efforts into astronomy-related careers
-
How WSU broadens health care career access for underrepresented, disadvantaged students
College to Career
-
Wayne State leaders’ research affirms transformative value of college education, importance of equitable access
-
College of Education student benefits from transfer pathway, scholarship on journey toward sports medicine career
-
Wayne State helps ‘Grow Detroit’s Young Talent,’ celebrates a decade of partnership fueling summer work experiences
-
Wayne State University College of Education awarded $1.25 million grant to strengthen special education instruction for students with disabilities
Fuel innovation
-
Wayne State drives advancements in health with cutting-edge technology
-
Professor inspires community college students to redirect academic efforts into astronomy-related careers
-
NSF CAREER grant supports Wayne State fluorescent protein study, student lab opportunities
-
Wayne State University awarded $1.3 million from Department of Defense to fine-tune augmented reality exposure therapy for PTSD
Empower health
-
Riding with the Wayne Mobile Health Unit
-
NIH funds critical center in Detroit to lead efforts to investigate and mitigate health impacts of community-voiced chemical and non-chemical stressors
-
State-of-the-art MRI will advance Wayne State research
-
Wayne State School of Social Work champions Collegiate Recovery Program to create a supportive and empowered college experience
Public Health
-
Riding with the Wayne Mobile Health Unit
-
NIH funds critical center in Detroit to lead efforts to investigate and mitigate health impacts of community-voiced chemical and non-chemical stressors
-
Wayne State University experts warn of potential threats due to low vaccination rates in Michigan; stress importance of immunization
-
Wayne State graduates empower urban health