DETROIT – A team of researchers from Wayne State University received a nearly $2.7 million government grant under the auspices of the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health for the study, “Infusion device optimization by addressing root causes of the inflammatory response.”
Although insulin infusion systems for diabetes continue to improve, their lifespan is limited to three days, as the device insertion itself leads to inflammation and localized injury. Moreover, the preservatives used to stabilize insulin are also tissue toxic.
“All of the commercially available insulin formulations contain phenolic preservatives that prolong insulin shelf life but also cause tissue injury,” stated Ulrike Klueh, Ph.D., associate professor of biomedical engineering in Wayne State University’s College of Engineering. “Our team is focused on methods that reduce these preservatives’ tissue toxicity.”
Klueh and her research team reported that these devices induce mast cell activation and subsequent leukocyte recruitment, which initiates inflammation. Thus, overcoming these tissue toxic reactions represents a significant advancement in the goal to achieve normal blood sugar levels in diabetic patients.
The award number for this grant is DK129681. For more information, visit reporter.nih.gov/search/AfHuVJurFk-jAdeG_kjvCg/project-details/10443241#details.
About Wayne State University: Wayne State University is one of the nation’s pre-eminent public research universities in an urban setting. Through its multidisciplinary approach to research and education, and its ongoing collaboration with government, industry and other institutions, the university seeks to enhance economic growth and improve the quality of life in the city of Detroit, state of Michigan and throughout the world. For more information about research at Wayne State University, visit research.wayne.edu.
December 2, 2022
Wayne State researchers aim to improve the future of diabetes therapy
Share
Contact
Health
-
WSU scientists discover new stress hormone that counteracts metabolic disorders
-
Wicked weather brings carbon monoxide warnings from Michigan Poison & Drug Information Center
-
Wayne State researchers aim to improve the future of diabetes therapy
-
WSU alumnus finds remedy for his artery disease
Diversity, Equity and Inclusion
-
Hafner named recipient of 2023 Michigan Chronicle Women of Excellence Award
-
WSU community engages Detroit students at Chrysler Elementary School
-
Wayne State University Detroit Equity Action Lab to host the National Day of Healing from Racism
-
Wayne State to host two-day MLK tribute to mark 60th anniversary of the March on Washington
Innovation
-
Wayne State researchers win MTRAC competition and receive $100,000 to further LaSonics sound detection technology
-
Wayne State Library System publishes second book as part of Open Textbook Project
-
Social media connection leads alumnae to launch Love of Literacy Foundation
-
Wayne State University and Karmanos Cancer Institute express gratitude for $100 million from state for new medical education-research site
Arts
-
Social Work Peer Support group publishes first poetry and art journal
-
Juanita Anderson among documentarians worldwide to receive Ford Foundation's JustFilms grant support
-
‘Black Panther: Wakanda Forever’s’ Ivy Haralson epitome of Warrior strength
-
Wayne State University to to unveil historical mural at the School of Medicine Sept. 18
Honors & awards
-
Hafner named recipient of 2023 Michigan Chronicle Women of Excellence Award
-
Juanita Anderson among documentarians worldwide to receive Ford Foundation's JustFilms grant support
-
Wayne State researchers win MTRAC competition and receive $100,000 to further LaSonics sound detection technology
-
Dr. Shira Heisler earns Wayne State Warriors of Distinction Alumni Award