A major new pediatric clinical trial, funded by the National Institutes of Health and published this week in the New England Journal of Medicine, has "major implications" for the treatment of urinary tract infections (UTIs) in millions of American children, according to a Children's Hospital of Michigan pediatrician-researcher who played a key role in the study, which was initiated nine years ago. The largest clinical trial of its kind ever to be conducted in the world, the study provides convincing evidence that children with a common urinary-tract abnormality known as "vesicoureteral reflux" (or "VUR") experience a significantly reduced risk of developing frequent UTIs when treated with long-term low-dose antibiotics. "This newly published study has major implications for the management of UTIs in children," said Dr. Tej Mattoo, Detroit Medical Center chief of pediatric nephrology and Wayne State University School of Medicine pediatrics professor. "According to the study, we now have a much clearer understanding of the relationship between UTI and VUR, and that has clinical implications that are very positive, indeed," Mattoo said.

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http://www.digitaljournal.com/pr/1901112#ixzz312LuPMnN
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