After the left ventricle of the heart contracts, it must relax efficiently to prepare to refill and supply the body with blood on the next beat.  An increasing number of patients — including nearly all patients with heart failure — suffer from impaired relaxation, which is part of a clinical syndrome known as diastolic dysfunction. Currently, treatments for impaired relaxation do not exist. A team of Wayne State University School of Medicine researchers led by Charles Chung, Ph.D., assistant professor of physiology, recently received a $1,894,271 grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to address the critical need for new drug targets and diagnostic indexes for diastolic dysfunction using novel biomechanical tests that ultimately can be translated into clinical practice. According to Chung, the project was inspired by his research team’s finding that how quickly the heart’s muscle moves is directly related to how fast the muscle can relax. The project will use unique experiments and imaging techniques to link mechanical properties of the heart with models of heart failure that occur in patients. “My lab’s main research focus is to understand how the heart muscle moves at the end of contraction and how this motion can speed up the force decline, or relaxation, of the muscle,” said Chung. “Major proteins in muscles called myosin, actin and titin control the force of each beat. When the heart muscle contracts, myosin binds to actin to generate force. Our lab is trying to determine if motion — and how fast the motion occurs — makes myosin let go of actin faster and make the muscle relax faster.” 

Spotlight on the News interviewed two Michigan legal experts about the second Donald J. Trump presidential impeachment trial. Guests included Professor Richard Primus of the University of Michigan Law School and Professor Jonathan Weinberg of Wayne State University Law School. Primus and Weinberg looked at the important constitutional issues and politics facing the U.S. Senate jurors who will judge this historic trial.

Children have been less impacted by COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SAR-CoV-2) than adults. But some children diagnosed with SARS-CoV-2 have experienced severe illnesses, including Multisystem Inflammatory Syndrome (MIS-C) and respiratory failure; nearly 80% of children with MIS-C become critically ill with a 2 to 4% mortality rate. Currently, there are no methods to discern the spectrum of the disease’s severity and predict which children with SARS-CoV-2 exposure will develop severe illness, including MIS-C. Because of this, there is an urgent need to develop a diagnostic modality to distinguish the varying phenotypes of disease and risk stratify disease. To prevent children from becoming critically ill from SARS-CoV-2, a team of Wayne State University researchers led by Dongxiao Zhu, Ph.D., associate professor of computer science in the College of Engineering, are developing an artificial intelligence (AI) model to aid in the early detection of severe SARS-CoV2 illness in children.

In recent months, the issue of social justice and its connection to systemic racism and oppression have led to significant shifts in our collective thinking about the ways white supremacy persists in so many aspects of American life. These important conversations have been long in the making. In addition to having frank discussions about biased policies and uprooting unconscious racism, this moment is also bringing to light the importance of narrative equity and having the kind of balance in storytelling that make audiences feel more connected to the media they consume. One new offering that is tied to this shifting media paradigm is the new podcast, “Seizing Freedom.” It takes listeners back to the lessons about the Civil War and the Emancipation Proclamation and into the work that Black Americans did to battle for and secure their own freedom. Kidada Williams is a Wayne State University professor, author and historian who studies what happened to African American survivors of racist violence. She’s also the host of the new podcast, “Seizing Freedom.” Williams says children are often not told about the role of African Americans in securing their own freedom. “If it’s not erased altogether, it’s distorted,” says Williams. “Coming up through school, we didn’t learn about Black people during the Civil War, we didn’t learn about Black people during Reconstruction,” she continues. “What was made clear to me when I raised questions was this was a White man’s war and a White man’s history of it.” She also shines light on the fact that the struggle for freedom didn’t come easy. ”Freedom isn’t something that’s given to African Americans. They had to seize it during the Civil War. And once they gained legal freedom, they had to work to make it real.”

While the number of immigrants from Arab countries to the United States has steadily increased over the past several years, family and child health research on this population remains scarce. To address this disparity, Dalia Khalil, Ph.D., RN, assistant professor in Wayne State University's College of Nursing, was recently awarded a two-year, $161,451 grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health. Khalil and her team will expand on her previous research on immigrant Arab American parents and families.

Researchers at Wayne State University are working to bring micro-transit solutions to those who live in affordable housing so they can get to their jobs. The National Science Foundation is helping to fund the project. Micro-transit, which exists between traditional transit options such as buses and ride-hailing technology, is designed to complement public transportation. Detroit and other cities have begun to adopt the concept, the researchers say, as a means of increasing coverage and reaching more people, particularly in low-density or low-income areas. However, there is a shortcoming — the service often isn’t available on paths between areas of affordable housing and employment opportunities. “With the rise of artificial intelligence and increasingly available smart mobility data, the vision of this research project is to create a dynamic routing-prediction system based on learning the hourly mobility patterns between jobs and housing,” says Dongxiao Zhu, associate professor of computer science in the College of Engineering at Wayne State, and the project’s principal investigator. The researchers will design an artificial intelligence-assisted micro-transit system that transportation officials can deploy to better adapt to place and time variations in the mobility patterns of hourly workers. Geocoded socioeconomic data can be used to identify and reduce mobility disparities. “The research innovation is expected to provide immediate, low-cost, effective public transit solutions that benefit vulnerable communities in Detroit by significantly reducing transit risk, commute time and distance, and trip cost,” says Zhu.

Wayne State University’s Dr. Paul Kilgore discusses the latest developments around COVID-19 and what Michiganders can do to remain vigilant in slowing the spread of the virus. Many people are hopeful that the COVID vaccine is a light at the end of a nearly year-long tunnel that has taken Americans very far away from what life was like pre-pandemic. But now, as Michigan and other states are struggling to get the vaccine distributed, there’s an even bigger obstacle: The emergence of several new variants of the coronavirus. “The virus is actually changing its genetic code. It’s changing over time. All viruses do that, and we expected it from the beginning,” says Kilgore, associate professor and director of research at Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences. He’s also the principal investigator at Henry Ford Health System’s testing of Moderna’s vaccine trial. As far as the severity of COVID-19 symptoms in the new variants, Kilgore says there is some research indicating that these mutations could create more complicated cases of the virus. In looking ahead to how these new variants could impact the future of life in Michigan and throughout the country, Kilgore says, “I think there’s a chance this gets worse before it gets better in the next several weeks.”

It was a State of the State unlike any other, with Gov. Gretchen Whitmer speaking to Michiganders virtually from her Capitol office on Wednesday night. As expected, the governor focused heavily on the pandemic, vaccinations, the state's economy and schools. Despite the year it's been, the governor had a sense of optimism about the road ahead and that's something people noticed, including a political science professor at Wayne State University. Professor Marjorie Sarbaugh-Thompson was encouraged overall by the governor's address. She says bipartisanship will be key to the administration reaching its goals in 2021. Whitmer also addressed education. She's previously said she'd like to see students return to the classroom by March 1. “I think it’s going to be important just to get the younger kids back at least in smaller groups," Thompson said. “I’m a little bit concerned about how fast we’re going to be able to get the teachers vaccinated.”

The National Institutes of Health is supporting a Wayne State University School of Medicine physician-researcher’s work at preventing and treating cerebral palsy in the form of two new five-year R01 grants worth a collective $5.59 million. The principal investigator on both projects is Sidhartha Tan, M.D., professor and co-division chief of Neonatology in the Department of Pediatrics. Cerebral palsy is a group of disorders that affect a person’s ability to move and maintain balance and posture. CP is the most common motor disability in childhood, caused by abnormal brain development or damage to the developing brain that affects a person’s ability to control his or her muscles. Tan obtained his first R01 last May for “Potent Neuronal Nitric Oxide Synthase Inhibition for Prevention of Cerebral Palsy,” which will provide $2,393,590 over the half-decade award period to test new, promising drugs aimed at a preventive cure for the condition. “These are new drugs aimed at brain condition called neuronal nitric oxide synthase. New information about how these drugs act, how they affect brain cells and how effective they are in an animal model of cerebral palsy will be very valuable for future translation to clinical use in humans throughout the world,” Tan said. His second, a multiple principal investigator award launched Dec. 15, is “Probing Role of Tetrahydrobiopterin in Cerebral Palsy by Using Transgenic Rabbits.” The grant will provide $3,197,644 in funding over five years to explore whether an essential enzyme co-factor is involved in brain injury before birth. The cellular and genetic basis of brain regional injury will be investigated using an animal model in which genes have been altered by genetic engineering methods, as well as advanced methods of magnetic resonance imaging.

A small, liquid-filled sensor can continuously and accurately measure heart and lung sounds, detecting cardiac problems or shortness of breath at an early stage, something which could warn heart failure patients of health deterioration and also help pick up early signs of infections such as Covid-19. Many of us own smart watches or fitness trackers, a large number of which now include heart rate monitors. However, while their accuracy has improved, they offer fairly limited information about heart health. They mostly measure heart rate by shining a green light through the skin, a method called photoplethysmography, which controversially works much better on lighter rather than darker skin. Heart sounds, such as those heard by a stethoscope, can give a more accurate picture of heart health as they can pick up inconsistencies of rhythm as well as rate. But have been historically harder to track using a wearable device. To try and get round this problem, Yong Xu, a professor of electrical and computer engineering at Wayne State University, and his team have developed a small flexible sensor that can be worn continuously on the chest to measure heart and lung sounds. “Heart and respiration activities offer pivotal physiological and pathological information through mechano-acoustic signals. Continuous monitoring of these signals has the potential to significantly improve the diagnosis and management of many cardiovascular and respiratory diseases,” emphasizes Xu.

Prior to the November general election, three of the five Macomb County offices up for grabs were held by Democrat party members. The Macomb County Board of Commissioners was also a Democratic majority. But on Nov. 3, the positions of prosecutor and clerk/register of deeds shifted from Democrat to Republican, leaving the position of sheriff as the lone Democrat-held seat. Now, Peter Lucido is prosecutor and Anthony Forlini is clerk, while Larry Rocca, Candice Miller and Anthony Wickersham remain in their roles of treasurer, public works commissioner and sheriff, respectively. For the BOC, a couple commissioners indicated that it is the first time in the county’s history that the board has a Republican majority. So what does that mean for the people of Macomb County? Maybe not much, according to officials and experts. Wayne State University Professor Marjorie Sarbaugh-Thompson said she looks at county government in her Michigan politics class. She has been a political science professor at the university since 1991. When it comes to county government, she said for the position of public works commissioner, she would want one with a civil engineering background, regardless of party identification. Sarbaugh-Thompson believes placing a political party next to one’s name on a voting ballot helps voters decide. “On a ballot as long as Michigan’s, how do you figure out who you want for different positions, when you’ve never heard of these people?” Sarbaugh-Thompson said. “Many voters pick things based on party cues. It at least gives you a ballpark feel at the angle a particular candidate would come at an issue.”

Melba Boyd is a lifelong Detroit resident and distinguished professor of African American Studies at Wayne State University. Boyd has seen Detroit through its many forms and leadership. She had just graduated high school and was preparing to go to school at Western Michigan University when the Detroit 1967 Rebellion broke out. “The ‘67 rebellion was a critical moment in Detroit history and certainly in my own memory as a Detroiter. The incident was sparked as a consequence of an encounter with the police and these encounters were very frequent, unfortunately, and were almost always directed at people of color,” Boyd said. Almost a year after the ‘67 Rebellion, Rev. Martin Luther King Jr. was assassinated. As a young academic, this event directed her course of study and her interest in activism. “I’ll always remember that, because two days before [King] was killed, I turned 18, and in terms of my adult life, it really set forth you know what I was going to be about and eventually activism and academia have been my purpose,” Boyd said. 

COVID-19 has taken a toll on mental health in Michigan and across the world, but new Wayne State University research shows that burden has been heaviest for people of color. WSU researchers Peter Lichtenberg and Wassim Tarraf are examining how race, employment, and socioeconomic status intersect with pandemic-related stress, depression and anxiety. They've used U.S. census data to identify individuals to poll every two weeks about how their mental health has changed throughout the pandemic. "The findings that we have are pretty concerning," Tarraf says. "What we see through the data is a large percent of individuals who do report that they have mental health issues. What’s also concerning is these rates of mental health issues have remained stable over time. … People are not adapting and there are not enough tools for helping them reduce that level of stress. It is worth mentioning that rates are higher for people of color than those reported among whites." Lichtenberg and Tarraf also took stock of the social determinants of health that are affecting their subjects' mental health. "Food insecurity and job loss really stood out to us," Lichtenberg says. "65% of people with food insecurity had mental health issues. The numbers were similar for job loss in the household during the time of COVID-19."

Sylvia Taschka, senior lecturer of history, wrote a piece for The Conversation about the post Trump era. “Comparisons between the United States under Trump and Germany during the Hitler era are once again being made following the storming of the U.S. Capitol on Jan. 6. Even in the eyes of German history scholars like myself, who had earlier warned of the troubling nature of such analogies, Trump’s strategy to remain in power has undeniably proved that he has fascist traits. True to the fascist playbook, which includes hypernationalism, the glorification of violence and a fealty to anti-democratic leaders that is cultlike, Trump launched a conspiracy theory that the recent election was rigged and incited violence against democratically elected representatives of the American people. This is not to say that Trump has suddenly emerged as a new Hitler. The German dictator’s lust for power was inextricably linked to his racist ideology, which unleashed a global, genocidal war. For Trump, the need to satisfy his own ego seems to be the major motivation of his politics.”

Mark Satta, assistant professor of philosophy, wrote an article for The Conversation offering perspective on the term president-elect. “On Jan. 20, Joe Biden will be sworn in as president of the United States. Until then, he is president-elect of the United States. But what exactly does it mean to be president-elect of the United States? As a lawyer and philosopher who studies word meaning, I have researched the meaning and history of the term “president-elect” using publicly available resources like the Corpus of Historical American English – a searchable database of over 400 million words of historical American English text. I’ve also used Founders Online, which makes freely available many documents written by the nation’s founders. “President-elect” is not a term that is legally defined in U.S. law. Rather, the term’s meaning has developed over time through its use by the public. Its use can be traced all the way back to George Washington.”  

Even living in a time of isolation, the shockwaves that spread across the nation Wednesday were seismic. After insurrectionists stormed the U.S. Capitol, the first breach of its kind in more than two centuries, an insistence also arrived that the events were like something from another country. Strain of Violence raises the question is violence as American as apple pie? Kidada Williams, a Wayne State University historian who studies violence, would say yes. “Some scholars have argued that slavery and settler colonialism are the down-payment of the Revolution; they’re the down payment on American success,” said Williams in an interview with the Inquirer Thursday. “If you’re able to achieve significant success using violence, why would you use any other tactics?” Williams, who is writing a book on Black families who were attacked by the Ku Klux Klan amid Reconstruction, said the insurrection reminded her of the Civil War: The rebels were upset over election results, white progressives responded as a matter of preserving the country. The level of surprise this week at the attack at the Capitol, she said, reflects a deep belief in American exceptionalism that sidesteps our history of violence to focus on victories. America, she explained, erases its body count. “The federal government is expert at destabilizing movements that it perceives as a threat,” said Williams, who pointed to the American Indian Movement and the Black Power Movement. “The White Power movement has only recently been seen as a threat.”

Hilary A. Marusak, assistant professor of psychiatry and behavioral neurosciences, and Aneesh Hehr, Wayne State University medical student, wrote an article for The Conversation’s “Curious Kids” series. “When you’re asleep, you can seem completely dead to the world. But when you wake up, in an instant you can be up and at ‘em. How does the brain turn on awareness or consciousness? This question has puzzled scientists for centuries – and continues to do so. While scientists don’t have the full answer yet, they are finding clues by studying people’s brains as they shift between sleeping and waking.”

Michigan environmental law assigns responsibility for contamination not to the owners of the land, but to those who caused the pollution, however long ago, provided current property owners take some protective steps. Some 14,000 of the state's contaminated sites have no responsible party that can be identified — either it's unclear who caused it or those responsible no longer are around. That means the sites will fall to Michigan Department of Environment, Great Lakes and Energy (EGLE) and the U.S. Environmental Protection Agency EGLE or the EPA — taxpayers — to deal with as needed. And that number isn't likely to get reduced much anytime soon. Of those 14,000 sites, EGLE this year funded remediation activities at about 450. "Something is broken" in how Michigan handles its contaminated lands, said Carol Miller, professor of civil and environmental engineering at Wayne State University, a co-director of the university's Center for Leadership in Environmental Awareness and Research, or CLEAR. "There are more contaminated sites being left open than should be the case. The problem is dollars, and the problem is many, if not all, of these sites are legacy sites. Regulations against use of the sites, that doesn't solve the problem."

Kristin Taylor, associate professor in Wayne State’s Department of Political Science, co-authored an op-ed about the forthcoming vaccine and prospects for serious public participation. “The last few weeks have brought a key tool in the fight against coronavirus: Moderna recently announced that a vaccine in Phase 3 trials was nearly 95 percent effective, exceeding even the most optimistic projections. Pfizer and BioNTech have also made similar announcements. But excitement about a forthcoming vaccine has been tempered by the reality that more and more Americans report having serious reservations about getting vaccinated. Alongside further vaccine development, the incoming Biden administration will need a strategic communication and public outreach plan aimed at fighting what public health experts call vaccine hesitancy.”

For many Muslims, the real issue behind the travel restrictions is Islamophobia. Khaled Beydoun, a law professor at Wayne State University, warns against “only understanding Islamophobia through the Muslim ban” and remains skeptical about just how much Biden will do to root out systemic Islamophobia. “The Biden administration won’t engage in the same kind of Islamophobia as Trump does” but we may see a continuance of bombing countries like Yemen, Afghanistan and Pakistan, as well as sweeping domestic surveillance programs that target Muslims.