Will an aspirin a day keep COPD from flaring up?
A recent observational study suggests that aspirin might be instrumental in preventing flare ups of chronic pulmonary obstructive disease (COPD), thereby improving quality of life for those who suffer from breathing difficulties because of it. Of the 1,700 participants followed in the three-year study, 764 reported that they took aspirin daily. The aspirin users in the 2019 study reported fewer flare ups and less shortness of breath than participants in a control group that did not use aspirin. The COPD patients who took aspirin also did better on the 50-question St. George Respiratory Questionnaire score, which measures quality of life in patients with diseases of airway obstruction. While daily aspirin users reported a lower incidence of flare-ups, the findings need further confirmation, the authors write. “The study demonstrated only a small effect on moderate exacerbations and didn’t indicate that aspirin is as effective as other therapies in reducing exacerbations,” says Amber Lanae Martirosov, PharmD, MSc, BCPS, clinical pharmacy specialist ambulatory care at Henry Ford Health Systems, and clinical assistant professor in the Department of Pharmacy Practice at Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University. “The observational study design also provides some limitations and should be a starting point, not a reason to change clinical practice.” Martirosov urged caution when interpreting the results because ratios tend to overestimate data in research. “Additionally, the study did not provide information about dosing, adherence, or duration of aspirin therapy,” she says. “As such, we are not able to make sound recommendations about aspirin therapy in terms of dosing or duration.”
June 20, 2019