The 23rd annual Aline U. and James M. Orten Memorial Lecture will feature 2011 Nobel laureate Bruce Beutler, M.D., professor and director of the Center for the Genetics of Host Defense at UT Southwestern Medical Center.

The Oct. 10 lecture, presented by the Wayne State University Department of Biochemistry, Microbiology and Immunology, is scheduled to take place from 12:30 to 2 p.m. in the Margherio Family Conference Center adjacent to Scott Hall.

Dr. Beutler, who won the Nobel in Physiology or Medicine, will present "Using High Speed Forward Genetics to Study Immunity in Mice."

Dr. Beutler studied medicine at the University of Chicago. Early in his career he isolated mouse TNF and discovered its inflammatory properties. He later developed TNF inhibitor proteins that found widespread use in clinical medicine. Using genetics and taking the TNF response as a biological endpoint, he identified Toll-like receptor 4 as the mammalian sensor of bacterial lipopolysaccharides.

These groundbreaking studies of innate immune sensing and response earned Dr. Beutler the 2011 Nobel Prize in Physiology or Medicine.