Dr. Teena Chopra, a professor of infectious diseases at Wayne State University in Detroit, says the situation is starting to improve.

After giving his two cents at the White House, Detroit Mayor Mike Duggan returns to the city to try to steer it through the pandemic. Duggan talked about the challenges of the COVID-19 vaccine on Flashpoint. Then the “other” pandemic -- the mental health struggles of young people after a year of COVID-19. From the beginning, we’ve wondered about the toll the pandemic has been taking on all of us from a mental health standpoint. Studies are now making clear what many feared, that it’s having a deep and damaging impact on teenagers. There was a discussion on the issue with two health professionals including pediatrician Dr. Lynn Smitherman from Wayne State University and Mary Beth Garvey, a family therapist from Grosse Pointe.

Wayne County Chief Judge Timothy Kenny has been working to stop the spread of COVID-19. Through bond reductions and early releases, he's helped to send home over 400 inmates since last March. Close quarters, limited PPE, a high population due to mandatory sentencing guidelines and old buildings with poor ventilation have conspired to make correction facilities hotbeds for COVID-19. Michigan's prison system — the Michigan Department of Corrections — has gotten the most attention around this. Since the start of the pandemic, more than 135 inmates within the MDOC have died from COVID-19. One in two of the department's inmates have tested positive since March. But jails are battling many of the same issues. In addition to Judge Kenny — and others within the Third Circuit Court — pushing to release inmates, the jail has also ramped up its testing protocol, per Sheryl Kubiak, dean of Wayne State University's School of Social Work. Kubiak has worked with Chief of Jails Robert Dunlap to create a testing and contract tracing plan. "When COVID hit and we knew that the jail was in such trouble — we made a call and said what can we do to help," said Kubiak, who explained that at the time, they were just learning that people could have no symptoms and still transmit COVID-19. Working with Wayne State University's Medical School, they did a series of mass testing to find out what the prevalence rate was, decide who to isolate and make future plans.

Several companies have now made public their efforts to get workers vaccinated, including offering one-time bonuses and other financial incentives for employees who opt to get their shot. “Companies do have a lot of leeway in setting their own policies as to whether or not employees are going to have to receive the vaccine, but how the companies go about doing it can matter from a legal perspective," said Lance Gable, an associate professor at Wayne State Law School. It's a scenario not totally unfamiliar, Gable noted, as certain wellness incentives have been challenged in the past on the basis of discrimination. But the unique rollout of the COVID vaccine poses some never-before-seen problems too, he said. “There are separate issues about whether that is different if the vaccine has only been approved under Emergency Use Authorization. A mandatory vaccination requirement for a COVID vaccine could be permissible under federal law but only if employers put in place potential exceptions and accommodations," said Gable, citing EEOC guidance. In the EEOC's most recent guidance on wellness incentives, Gable said, it notes that any gifts or incentives companies offer should be modest, like a small gift card, lunch, or the cost of a ride, for example. Gable believes additional guidance will likely come out as the vaccine rollout continues.

Racial health disparities were known long before COVID-19 was a blip on a world news briefing in the U.S. Former U.S. Secretary of Health and Human Services Margaret Heckler wrote in a 1985 report from her Task Force on Black and Minority Health that such disparities have been present in federal records ever since accurate federal record-keeping began. And Heckler’s report, the first comprehensive study of racial and ethnic minority health by the U.S. government, looked at two years of averages and determined about 60,000 deaths, or 42.3% of deaths, of Black people under the age of 70 were considered “excess.” The report also determined six key factors, including cardiovascular disease, cancer, diabetes, and homicide, that drove higher death rates among Black people and it made recommendations to address the concerns, such as training in the medical community on cultural sensitivity, more education, and the gathering of more data. There hasn’t been a ton of progress since then, said Wayne State University President Dr. M. Roy Wilson. Wilson served as a deputy director at the National Institute on Minority Health and Health Disparities under the National Institutes of Health and is a member of the Michigan Coronavirus Task Force on Racial Disparities. “We understand a little bit more now about what some of the underlying issues are, but there are intractable issues …  some of them are things like education and income and other things which are bigger societal problems,” he said. COVID-19, with its fast onset, simply showed the results of health disparities faster than all the other illnesses health disparities cause, Wilson said. One thing isn’t talked about enough, said Wilson. That's how Michigan responded when the racial gaps in COVID-19 deaths were identified. The success has been “remarkable,” he said.

Many things in our pandemic-stricken world are very different. But perhaps the most striking change is how kids’ interactions with each other have transformed. Learning to socialize in the era of social distancing can be tougher than any subject offered in virtual school. When clinical psychologist Julie Wargo Aikins couldn’t leave her house last year without stepping on chalk drawings and spotting packs of kiddie cyclists, she realized something was changing when it came to kids and friendships. The associate professor at Wayne State University knew that prior to the pandemic, kids mostly formed friendships at school and through extracurricular activities. With the shift to remote learning and Zoom everything, the kids in her Michigan neighborhood had started getting noticeably closer to those who lived nearby. “Children are seeking out socialization where they’re at and interacting with children they wouldn’t have before,” says Aikins, who notes that as long as they wear masks and play outside, this is a healthy and welcome development. Through her ongoing research, adolescent developmental psychologist Hannah Schacter has found one early nugget of promising news: In a survey of about 400 ninth graders entering high school in the fall of 2020, about 90 percent reported having close friends. Schacter, an assistant professor at Wayne State University, says that indicates that these young people are managing to keep up connections in a time when extra support is critical. “In the face of stress—whether that’s being bullied or going through a global pandemic—no one wants to go through anything alone,” she says. Schacter adds that with friendship, quality may matter more than quantity. When it comes to fending off feelings of loneliness, the key difference is “between one and not having anyone,” she adds. But she is concerned by the fact that new friendship opportunities have been interrupted by COVID-19, forcing many kids into a funny game of “musical chairs” that has locked them into the relationships they had just before the pandemic. “For kids not in the healthiest friendships, it’s harder to escape those,” Schacter says. “There aren’t as many opportunities for informal friend building anymore, like sitting next to each other in math class."

Wayne State University School of Medicine researchers have reported that zinc supplements for men and women attempting to conceive either naturally or through assisted reproduction during the COVID-19 pandemic may prevent mitochondrial damage in young egg and sperm cells, as well as enhance immunity against the virus. In “Potential Role of Zinc in the COVID-19 Disease Process and its Probable Impact on Reproduction,” published in Reproductive Sciences, Husam Abu-Soud, Ph.D., associate professor of Obstetrics and Gynecology and the C.S. Mott Center for Growth and Development, said that in addition to benefiting couples attempting to conceive during the pandemic, zinc supplementation of up to a maximum of 50 mg per day for all adults could be beneficial in enhancing immunity and fighting the viral disease process of COVID-19. He also noted that zinc can be beneficial to the general population in enhancing immunity and fighting the viral disease process.

Children have been less impacted by COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SAR-CoV-2) than adults. But some children diagnosed with SARS-CoV-2 have experienced severe illnesses, including Multisystem Inflammatory Syndrome (MIS-C) and respiratory failure; nearly 80% of children with MIS-C become critically ill with a 2 to 4% mortality rate. Currently, there are no methods to discern the spectrum of the disease’s severity and predict which children with SARS-CoV-2 exposure will develop severe illness, including MIS-C. Because of this, there is an urgent need to develop a diagnostic modality to distinguish the varying phenotypes of disease and risk stratify disease. To prevent children from becoming critically ill from SARS-CoV-2, a team of Wayne State University researchers led by Dongxiao Zhu, Ph.D., associate professor of computer science in the College of Engineering, are developing an artificial intelligence (AI) model to aid in the early detection of severe SARS-CoV2 illness in children.

The Michigan Department of Health and Human Services (MDHHS) is partnering with Wayne State University and Wayne Health to provide mobile COVID-19 testing. The partnership comes in an effort to reach more Michiganders in need of COVID-19 testing and other public health services. This new program allows three mobile units to move between sites and serve communities at the highest risk. Locations are chosen in part to help address racial and ethnic disparities that had existed prior to the pandemic and were exacerbated by the virus – a focus of the Racial Disparities Task Force. Wayne Health’s Mobile Health Unit offers an array of health care screenings, including COVID testing, flu shots, blood pressure screening, HIV testing and on-site referrals for public benefit programs such as Medicaid and unemployment assistance and emergency food and shelter services addressing social determinants. “Partnering with the state will expand our efforts to bring these vital services to more Michigan residents who need them,” said Phillip Levy, M.D., M.P.H., who leads the Mobile COVID Testing Program for Wayne Health and is WSU’s assistant vice president for Translational Sciences and Clinical Research Innovation. “This work is a key element of who we are as a university and as a practice group. Meeting people and providing services where they live is critical not only to containing the COVID-19 pandemic, it is essential to improving health in general.” 

As the initial priority groups are being offered a COVID-19 vaccine in the U.S., one population in particular faces a difficult decision: Pregnant people who are health care personnel or essential workers—categories that are eligible for the early phases of the vaccination program—“may choose to be vaccinated,” according to the latest official guidance from the Centers for Disease Control and Prevention. The problem is that there are scant data available on the safety of COVID-19 vaccines in pregnant individuals. They were not included in the clinical trials, as has historically been the case with most vaccines and drugs. For many years, it was believed that pregnancy was a state of immunologic weakness. The fact that pregnant individuals died more from diseases such as influenza was attributed to this state. More recently, it became clear that immunologic changes in pregnancy were much more complex than that. “They were not dying because they were immunosuppressed,” says Gil Mor, scientific director of the C. S. Mott Center for Human Growth and Development at Wayne State University. “They were dying because their immune system was so strong and activated that they produced a massive inflammation that killed them.” Mor, who is an expert in the immunology of pregnancy, says there are several mechanisms to maintain the delicate balance between too much and too little inflammation during that state. If this balance is not maintained for any reason, the risk of severe COVID-19 symptoms rises.

Wayne State University’s Dr. Paul Kilgore discusses the latest developments around COVID-19 and what Michiganders can do to remain vigilant in slowing the spread of the virus. Many people are hopeful that the COVID vaccine is a light at the end of a nearly year-long tunnel that has taken Americans very far away from what life was like pre-pandemic. But now, as Michigan and other states are struggling to get the vaccine distributed, there’s an even bigger obstacle: The emergence of several new variants of the coronavirus. “The virus is actually changing its genetic code. It’s changing over time. All viruses do that, and we expected it from the beginning,” says Kilgore, associate professor and director of research at Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences. He’s also the principal investigator at Henry Ford Health System’s testing of Moderna’s vaccine trial. As far as the severity of COVID-19 symptoms in the new variants, Kilgore says there is some research indicating that these mutations could create more complicated cases of the virus. In looking ahead to how these new variants could impact the future of life in Michigan and throughout the country, Kilgore says, “I think there’s a chance this gets worse before it gets better in the next several weeks.”

Today, small groups of scientists, psychologists and other medical professionals are looking at psychedelics once again for the claims that they can be beneficial for those suffering from severe mental health issues. The movement for decriminalization has focused primarily on those efforts, although some proponents also advocate for those who choose to safely use psychedelics recreationally. Susanne Brummelte, professor of psychology at Wayne State University, said today the study and understanding of psychedelics is “an emerging field because it was illegal. They've been Schedule I drugs, so it's very difficult to do research, though there is beginning to be some research on the medical benefits of LSD, and they're getting some idea that with a guided trip it can help with depression and other issues.” Scott Bowen, professor and chair of the department of psychology at Wayne State University, said, “Decriminalization allows for some research to study depression, anxiety, mood enhancement. The question is, does it really happen? Unless there's a placebo – a negative – you don't have a scientific study to determine efficacy. There's a lot of anecdotal information that can be attributed to the placebo effect.” Bowen and Brummelte believe there needs to be more research on the medical benefits of microdosing, as well. “LSD is a powerful drug. It affects your serotonin receptors, so it will definitely change your brain,” said Bowen. “The question is, is that happening with microdosing? There are a lot of unknowns. It's just so new. LSD by itself is the most potent – you just need a teeny amount, but it is also the most effective.”

Wayne State University’s School of Medicine needs people to roll up their sleeves for research’s sake. The school is part of a nationwide clinical trial of a COVID-19 vaccine made by Novavax, Inc. Phase 3 of the trial will help scientists determine whether it’s effective at preventing infection. Dr. Elizabeth Secord is heading up WSU’s involvement in the trial. She says her team needs about 300 volunteers. “Two-thirds will get the vaccine, one third will get a placebo,” she says. “We can compare rates of COVID, look at antibodies and see the effectiveness of the vaccine.” At first, researchers wanted a large number of higher-risk candidates, such as people 65 and older, individuals with underlying health conditions and people of color. They can still enroll, but now that many older people are eligible to receive the Pfizer or Moderna vaccines, Wayne State is actively seeking younger volunteers for the study. “People who are, for example, 60, 50, 40, even in their 20s who are not likely to get a vaccine for several months,” Secord says. “It would be good for them to consider entering such a trial.” Unlike the Pfizer and Moderna vaccines, the Novavax COVID-19 vaccine does not use messenger RNA. Secord says she hopes that will encourage people to join the clinical trial, though she stresses that concerns about mRNA are unfounded, noting that she has already been vaccinated. “I think that this vaccine will be safe, the other vaccines are safe, and that people should take what they can get as soon as they can get it,” she says. If the Novavax vaccine passes its trials, Secord says she hopes it will be approved for emergency use within six months.

Wayne State University President M. Roy Wilson, Michigan State President Samuel L. Stanley Jr.,  and University of Michigan President Mark S. Schlissel wrote an op-ed regarding the COVID-19 vaccine as a means to stop the pandemic. “As presidents of the three major public research universities that make up Michigan’s University Research Corridor — Michigan State University, the University of Michigan and Wayne State University — we’ve been on the front lines of battling the COVID-19 pandemic. URC researchers have worked to develop tests, treat the virus and create vaccines. We’re training thousands of physicians, nurses and other health care workers in dealing with the virus. We’re helping educators, business owners and government officials deal with the challenges of COVID-19. As COVID-19 case counts continue to rise across the United States, getting everyone possible vaccinated as soon as enough doses are available is vital to stopping this pandemic, reviving our national economy and getting children and college students back to in-person school. The alternative is what we have now: high caseloads that are overwhelming our hospitals and health care workers, and millions of students able to attend classes only online. Our economy will continue to falter and layoffs will increase as the coronavirus makes it unsafe to shop and dine as we normally do. Family gatherings and large meetings will remain off limits or, if held, become potential superspreader events.”

Mustapha Al-shorbaji is a nursing student at Wayne State University. He sits in the lobby of the Campus Health Center with a black mask on, waiting to get a COVID-19 vaccine. “As soon as I was presented the opportunity, I took the first appointment I could get to come here,” says Al-shorbaji. Wayne State University began offering the vaccine to medical students and faculty with clinical rotations on January 7. That’s how Al-shorbaji found himself among the first people in the country to be given the chance to be inoculated against the coronavirus. In addition to frontline health care workers, vaccinations throughout Michigan have been given to some people in long-term care facilities, police officers, bus drivers, K-12 teachers, postal workers, people over the age of 65 and others. Eligibility varies depending on where people live, work, or go to the doctor. As of January 19, according to data from the Michigan Department of Health and Human Services, about 75,800 people in Michigan have received at least the first dose of the vaccine. In a state that’s estimated to have roughly 8 million people age 16 and up (according to the US Census Bureau’s American Community Survey), that means less than 1% of the population has been vaccinated.

Dr. Herbert C. Smitherman Jr., vice dean of diversity and community affairs and a professor of medicine at Wayne State University School of Medicine, wrote an opinion piece discussing why we all should take the COVID vaccine. “The pace at which African Americans are dying has transformed this national health crisis into an abject lesson on racial and class inequality. African-Americans are more likely to die of COVID-19 than any other ethnic group in the nation. That’s why Black Americans — and all Americans — must be vaccinated against COVID. As an African-American male, I all too well understand the current mistreatment and the historic abuse of Black people in the United States. However, we as Americans, including all communities of color need to separate science from the recent political administration’s antics and society’s construct of race. There is only one race, the human race. Coronavirus is disproportionately killing people of color, not because of race but because of centuries of negative, oppressive and disparate social, economic, political, and health policies that result in disparate and inequitable living conditions in our society.”

COVID-19 has taken a toll on mental health in Michigan and across the world, but new Wayne State University research shows that burden has been heaviest for people of color. WSU researchers Peter Lichtenberg and Wassim Tarraf are examining how race, employment, and socioeconomic status intersect with pandemic-related stress, depression and anxiety. They've used U.S. census data to identify individuals to poll every two weeks about how their mental health has changed throughout the pandemic. "The findings that we have are pretty concerning," Tarraf says. "What we see through the data is a large percent of individuals who do report that they have mental health issues. What’s also concerning is these rates of mental health issues have remained stable over time. … People are not adapting and there are not enough tools for helping them reduce that level of stress. It is worth mentioning that rates are higher for people of color than those reported among whites." Lichtenberg and Tarraf also took stock of the social determinants of health that are affecting their subjects' mental health. "Food insecurity and job loss really stood out to us," Lichtenberg says. "65% of people with food insecurity had mental health issues. The numbers were similar for job loss in the household during the time of COVID-19."

Wayne State University has begun issuing COVID-19 vaccines to medical students and faculty who work on the frontlines. The plan is to inoculate 120 people per day with Moderna and Pfizer vaccines which are being supplied by the Detroit Health Department. “Right now we have people who have been categorized as essential. Those are individuals who are actually touching patients in the hospital,” says Dr. Toni Grant, the Chief Nursing Officer at the Wayne State University Campus Health Center, where the vaccinations are taking place. Grant says these essential workers were emailed a survey to see if they were interested in receiving the vaccination. Those who said they wanted the shot and are eligible for it are being emailed specific instructions on how to schedule an appointment. These emails are coming out in batches, so some may not be able to make their appointment for a couple of weeks. Bill Fulson is a clinical nursing instructor with Wayne State who came into the Health Center to get the vaccine. He says he doesn’t feel any anxiety about receiving the vaccine. “I have no reason to feel not confident,” says Fulson. “I’ve been nursing for 40-something years. So you know when to do things and when not to do things. And this is a must-do for a medical professional.” Grant says the vaccinations are a great opportunity for the Wayne State community. “We’re in the midst of a pandemic but this is also something that none of us have ever gone through before,” she says. ”And to actually see what research and science can do in order to get us through to this particular point, it’s exciting because it’s students, faculty and staff together and able to experience it firsthand.”

Vaccine distribution continues to slowly trickle down the ranks as Wayne State University's students and faculty in front-line health professions got their turn Thursday to begin getting inoculating against COVID-19. Wayne State began administering the first dose of the Moderna vaccine to faculty and students who are in active clinical practice and rotations with patients. "We were able to invite individuals to let us know if they were interested in receiving the vaccine. Those that were interested in receiving the vaccine received an invitation to continue to the process," said Toni Grant, chief nursing officer at Wayne State's Campus Health Center. Approximately 2,000 people were identified by Wayne State as having first priority to the vaccine due to constant exposure working in hospitals. Wayne State is able to administer the vaccine in phases under a memorandum of understanding with the Detroit Health Department. "Wayne State is not mandating that anyone received the vaccine, but it is being highly encouraged that they receive it," said Grant. "One of the things that we wanted to make sure is that everyone was well-informed before they even scheduled their appointment, so all the information was actually made available electronically."

To date, tens of thousands of Michigan residents have received the new COVID-19 vaccines, an inoculation rate far below the original projected goal of elected officials. The slow rollout has concerned citizens and public health experts alike, and speed isn’t the only issue facing distribution efforts: Vaccine hesitancy is proving to be a major hurdle as well. Concerns about vaccine safety are coming from various groups, including anti-vaxxers who view this moment as an opportunity to promote their anti-science agenda. While others simply don’t trust the development process, Black Americans have expressed legitimate skepticism of the vaccine based on the fact that the Black community has been historically taken advantage of when it comes to the medical system, as evidenced by the Tuskegee syphilis study among other things. Dr. M Roy Wilson, president of Wayne State University, and Dr. Paul Kilgore, associate professor & director of research at the Eugene Applebaum College of Pharmacy and Health Sciences and the principal investigator at Henry Ford Health System’s testing of Moderna’s vaccine trial, participated in a discussion and responded to listener’s questions about the COVID-19 vaccine.